Effects On P450 Enzymes

Tests Performed On Human Subjects

Cytochrome P450 Enzyme Effect Dosage
CYP1A2 Potential induction[2] ?
CYP3A4 Moderate inhibition[2] ?
CYP2C9 Strong inhibition[2] ?
CYP2D6 Strong inhibition[2] ?
CYP2E1 Strong inhibition[3] 500 mg once daily for 10 days

Tests in human volunteers found that resveratrol increased the metabolism of caffeine via a route known to occur by CYP1A2, suggesting that it induces CYP1A2.[2]

Tests in human volunteers found that resveratrol appeared to strongly inhibit CYP2D6, very strongly inhibit CYP2C9, and moderately inhibit CYP3A4.[2]

Other tests in humans found that resveratrol potently inhibited CYP2E1.[3]

Tests Performed In Vetro

Resveratrol was found to inhibit CYP1A2 in vitro with an IC50 of 0.79 ┬ÁM.[1]

Effects On GST and UGT1A1

In most human volunteers resveratrol was found to only weakly induce GST and UGT1A1, but was found to potently induced GST and UGT1A1 in individuals with low baseline levels of GST and UGT1A1.[2]

Chemical Properties

PubChem Compound ID: 445154
Molecular Weight: 228.24328 [g/mol]
Molecular Formula: C14H12O3
XLogP3-AA: 3.1
H-Bond Donor: 3
H-Bond Acceptor: 3
IUPAC Name: 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
InChI: InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
Canonical SMILES: C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O
Isomeric SMILES: C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O

1. Cell-based high-throughput bioassays to assess induction and inhibition of CYP1A enzymes.
Yueh MF, Kawahara M, Raucy J. PubMed PMID: 10448061
Resveratrol Modulates Drug- and Carcinogen-Metabolizing Enzymes in a Healthy Volunteer Study H-H. Sherry Chow, Linda L. Garland, Chiu-Hsieh Hsu, Donna R. Vining, Wade M. Chew, Jessica A. Miller, Marjorie Perloff, James A. Crowell and David S. Alberts; DOI: 10.1158/1940-6207.CAPR-09-0155 Published September 2010; PubMed PMCID: PMC2933312; NIHMSID: NIHMS207754
3. Resveratrol Pretreatment Affects CYP2E1 Activity of Chlorzoxazone in Healthy Human Volunteers.
Bedada SK, Neerati P.; Phytother Res. 2016 Mar;30(3):463-8. doi: 10.1002/ptr.5549. Epub 2015 Dec 17.; PMID: 26680654; DOI: 10.1002/ptr.5549
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