
Effects On P450 Enzymes
Tests Performed On Human Subjects
Cytochrome P450 Enzyme | Effect | Dosage |
---|---|---|
CYP1A2 | Potential induction[2] | ? |
CYP3A4 | Moderate inhibition[2] | ? |
CYP2C9 | Strong inhibition[2] | ? |
CYP2D6 | Strong inhibition[2] | ? |
CYP2E1 | Strong inhibition[3] | 500 mg once daily for 10 days |
Tests in human volunteers found that resveratrol increased the metabolism of caffeine via a route known to occur by CYP1A2, suggesting that it induces CYP1A2.[2]
Tests in human volunteers found that resveratrol appeared to strongly inhibit CYP2D6, very strongly inhibit CYP2C9, and moderately inhibit CYP3A4.[2]
Other tests in humans found that resveratrol potently inhibited CYP2E1.[3]
Tests Performed In Vetro
Resveratrol was found to inhibit CYP1A2 in vitro with an IC50 of 0.79 µM.[1]
Effects On GST and UGT1A1
In most human volunteers resveratrol was found to only weakly induce GST and UGT1A1, but was found to potently induced GST and UGT1A1 in individuals with low baseline levels of GST and UGT1A1.[2]
Chemical Properties
PubChem Compound ID: 445154
Molecular Weight: 228.24328 [g/mol]
Molecular Formula: C14H12O3
XLogP3-AA: 3.1
H-Bond Donor: 3
H-Bond Acceptor: 3
IUPAC Name: 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
InChI: InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
InChIKey: LUKBXSAWLPMMSZ-OWOJBTEDSA-N
Canonical SMILES: C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O
Isomeric SMILES: C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O