Pomegranate is a great source of gallic acid and ellagic acid.
Pomegranate juice contains 79.49 mg of gallic acid equivalent per liter as ellagitannins.[3] The various ellagitannins include granatin A and B, punicacortein A, B, C and D, 5-O-galloylpunicacortein D, punicafolin, punigluconin, punicalagin, 1-alpha-O-galloylpunicalagin, punicalin and 2-O-galloyl-punicalin. Other phenolics include delphinidin, cyanidin, and pelargonidin.
Pelargonidin is a potent inhibitor of MAO-B. Cyanidin and delphinidin are a moderate inhibitors of MAO-B.
Gallic acid induces Estradiol 17beta-dehydrogenase oxidation by 30%.[4] It also induces SULT1A1 and SULT1A3.[5] It also inhibits xanthine oxidase and aldehyde dehydrogenase.
Ellagic acid is a potent inhibitor of glutathione S-transferase enzymes GSTA1-1, GSTA2-2, GSTM1-1, GSTM2-2, and GSTP1-1.[6]
Cytochrome P450 Enzyme Interactions
Enzyme Inhibited | Interaction | Dosage | Verified In Humans |
---|---|---|---|
CYP1A1 [1] | Inhibition | ? | In mice only |
CYP1A2 [1] | Inhibition | ? | In mice only |
CYP2C9 [2] | None | 1 gram extract and unspecified amount of juice | Yes |
CYP2E1 [1] | Inhibition | ? | In mice only |
CYP3A [1] | Inhibition | ? | In mice only |