P-Glycoprotein

P-Glycoprotein (permeability glycoprotein, abbreviated as P-gp or Pgp) is a well-characterized ABC-transporter which transports a wide variety of substrates across extra- and intracellular membranes.

P-gp aids in absorption of drugs through the skin.[1] In the intestines P-gp prevents the absorption of drugs through the intestines by transporting them back into the intestines.

P-Glycoprotein (P-gp) Inhibitors and Inducers

Inhibitors Strength Dosage Verified in Man
African potato [3] ? ? ?
Apricot [3] ? ? ?
Bergamottin [3] ? ? ?
Biochanin A [3] ? ? ?
Black pepper [3] ? ? ?
Catechin [3] ? ? ?
Curcumin [3] ? ? ?
Galangin ? ? ?
Garlic [3] ? ? ?
Genistein [3] (in Kudzu) ? ? ?
Ginko [3] ? ? ?
Ginseng [3] ? ? ?
Green tea [3] ? ? ?
Hesperitin [3] ? ? ?
Isoquercitrin [3] ? ? ?
Kaempferol [3] ? ? ?
Milk Thistle [3] ? ? ?
Mint [3] ? ? ?
Morin [3] ? ? ?
Naringenin [3] ? ? ?
Naringin [3] ? ? ?
Onion [3] ? ? ?
Orange [3] ? ? ?
Phloretin [3] ? ? ?
Pomegranate juice (in vitro) ? ? ?
Quercetin [3] ? ? ?
(R)-(+)-citronellal [3] ? ? ?
Rosemary extract [3] ? ? ?
Rutin [3] ? ? ?
(S)-(-)-beta-citronellol [3] ? ? ?
Silymarin [3] ? ? ?
Spiraeoside [3] ? ? ?
Strawberry [3] ? ? ?
Tangeretin [3] ? ? ?
In Vitro Inhibitors Ineffective in Man Strength Dosage Verified in Man
Grapefruit Juice [2] ? 1 cup daily Yes
Inducers Strength Dosage Verified in Man
Adriamycin [3] ? ? ?
Cyclosporin A [3] ? ? ?
Daunomycin [3] ? ? ?
Dexamethasone [3] ? ? ?
Mitoxantrone [3] ? ? ?
Saint John's Wort [3] [4] ? ? Yes
Bibliography
1. J Control Release. 2008 Nov 12;131(3):198-204. doi: 10.1016/j.jconrel.2008.08.004. Epub 2008 Aug 12.
P-glycoprotein (Abcb1) is involved in absorptive drug transport in skin; Ito K, Nguyen HT, Kato Y, Wakayama T, Kubo Y, Iseki S, Tsuji A. Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan; PubMed PMID: 18725258
2. Grapefruit juice ingestion significantly reduces talinolol bioavailability
Ute I. Schwarz, MD, Diana Seemann, MD, Reinhard Oertel, PhD, Stephan Miehlke, MD, Eberhard Kuhlisch, PhD, Martin F. Fromm, MD, Richard B. Kim, MD, David G. Bailey, PhD, and Wilhelm Kirch,MD; Schwarz et al; CLINICAL PHARMACOLOGY & THERAPEUTICS; APRIL 2005 (Download Attached PDF Document)
3. Emerging Significance of Flavonoids as P-Glycoprotein Inhibitors in
Cancer Chemotherapy Tripta Bansal, Manu Jaggi, Roop K Khar and Sushama Talegaonkar; J Pharm Pharmaceut Sci (www. cspsCanada.org) 12 (1): 46 - 78, 2009 (Download Attached PDF Document)
4. Shu-Feng Zhou, Zhi-Wei Zhou, Chun-Guang Li, Xiao Chen, Xiyong Yu, Charlie
Changli Xue, and Adrian Herington Identification of drugs that interact with herbs in drug development; Drug Discovery Today 12(15-16):pp. 664-673; Adrian (2007) (Download Attached PDF Document)
Unless otherwise stated, the content of this page is licensed under Creative Commons Attribution-ShareAlike 3.0 License