Oilahuasca Activators

This is a supplement to the main article found here: Oilahuasca Activation.

The information presented in this article is mostly obtained from anecdotal reports. The data presented here needs to be verified by more individuals. If any data is missing from this article, or present in this article that is in conflict with other reports, please inform us by leaving a comment about it using the Discuss link at the bottom of this article.

Oilahuasca Activators are herbs and compounds found to help activate allylbenzenes in some but not all individuals. Some activators have been helpful in some people but detrimental in others.


Oilahuasca Diet

For 24 hours prior to using oilahuasca you must follow the Oilahuasca Diet restrictions.

Please note that the items in this article require that the Oilahuasca Diet is followed for 24 hours prior to using oilahuasca. If the Oilahuasca Diet is not followed Oilahuasca Activation can fail despite using the various oilahuasca activators given in this article.


Oilahuasca Enzyme Interaction

Most of the oilahuasca activators in this article are based on data pertaining to enzymes which interact with allylbenzenes. The chart below outlines several enzymes that need to be induced and inhibited.

The major human enzymes to induce (+) and inhibit (-) for Oilahuasca Activation.

SSAO 17bHSD2 ADH ALDH UGT1A9 UGT2B7 SULT1A1 SULT1A3 GST
- + + - - - - - -
Cytochrome P450 Enzyme Subfamilies
1A1 1A2 1B1 2A6 2B6 2C19 2C8 2C9 2D6 2E1 2J2 3A4
- +/- - + - +/- ? - - + - -

BBS 2 Stage Oilahuasca Activation Formula

Oilahuasca Activation formulas have been a work in progress since 2008. The latest BBS formula is based on berberine and steviosides developed in 2016. This formula looks very promising. This formula takes advantage of all the latest known methods of boosting success rates for Oilahuasca Activation. This formula works by inhibiting several enzymes known to inactivate allylbenzenes and induces enzymes known to help activate allylbenzenes.

Oilahuasca Activation formulas prior to 2016 are less effective. As more research is made, it's becoming much clearer which enzymes need to be inhibited and which ones need to be induced to help activate allylbenzenes.


Old Three Stage Oilahuasca Activation Formulas

This section contains old activation formulas prior to 2016. These formulas are not as effective.

These older Oilahuasca Activation formulas were created in 2013 based on research spanning only 5 years. Since these were created knowledge on Oilahuasca Activation has expanded, making these formulas obsolete.

STAGE 1 - DEPLETE GLUTATHIONE

For this cinnamon oil is taken used. The [cinnamaldehyde in cinnamon oil is used to deplete glutathione. This is a critical step to activating allylbenzenes. Cinnamaldehyde takes some time to deplete glutathione and should be taken before the allylbenzenes by at least 1 hour, and not with them. By taking it 2 days in a row it should be much more effective at depleting glutathione.

STAGE 2 - INHIBIT AND INDUCE ENZYMES

In this stage, taken 30 minutes after stage 1, herbs and supplements are taken that together inhibit CYP2D6, CYP3A4, UGT2B7, UGT1A9, SULT1A1, SULT1A3, and GST, and induce CYP2C9 and 17bHSD2. Is it very important that 17bHSD2 is strongly induced. If any food or supplements are taken that inhibit it, such as supplements, foods or drinks containing quercetin, then the allylbenzenes can not produce psychedelic effects.

STAGE 3 - AMINATION
In this stage we take the allylbenzenes together with a source of amines the allylbenzenes can condense with after they form 1'-oxo metabolites (such as 1'-oxoelemicin, 1'-oxoestragole, etc.). The amines should be taken in abundance with at least a 2:1 ratio or more, and should be safe to ingest at the doses used.

BP3 Three Stage Oilahuasca Activation Formula

This formula is based on piperidine. It's currently not known how formulas based on piperidine actually work. The piperidine metabolites of allylbenzenes are probably not psychedelic themselves, but may possibly act as protectors of the true psychedelic metabolites.

This formula works with elemicin, dillapiole, myristicin, methyl chavicol, and methyl eugenol. In this example elemicin is used. If using other allylbenzenes you might need to adjust the dosage of the allylbenzenes used. In general most allylbenzenes are active in the dosage range of mescaline.

ELBP3 is used to describe the BP3 formula when used with elemicin, where the prefix EL means elemicin. Similarly use the prefix MC for methyl chavicol, ME for methyl eugenol, MY for myristicin, SA for safrole, DA for dillapiole, AP for apiole, GA for gamma-asarone, etc.

The ELBP3 three sage Oilahuasca Activation formula produced psychedelic effects in several individuals. The main effects lasted 8 hours, with residual effects lasting up to 16 hours. This formula is designed to theoretically create 1'-oxoelemicin-pideridine in vivo. Anecdotal reports indicate that the ELBP3 Oilahuasca Activation formula produces effects similar to mescaline with an LSD-like electric feel.

PEA3 Three Stage Oilahuasca Activation Formula

This formula works with elemicin and probably works with other allylbenzenes. In this example elemicin is used.

If using other allylbenzenes you might need to adjust the dosage of the allylbenzenes used. In general most allylbenzenes are active in the dosage range of mescaline.

ELPEA3 is used to describe the PEA3 formula when used with elemicin, where the prefix EL means elemicin. Similarly use the prefix MC for methyl chavicol, ME for methyl eugenol, MY for myristicin, SA for safrole, DA for dillapiole, AP for apiole, GA for gamma-asarone, etc.

The ELPEA3 three sage Oilahuasca Activation formula produced very long lasting psychedelic effects in several individuals. The main effects lasted 12 hours, with residual effects lasting up to 48 hours. This formula theoretically creates 1'-oxoelemicin-PEA in vivo. Anecdotal reports indicate that the ELPEA3 Oilahuasca Activation formula produces effects similar to a cross between mescaline and XTC.


Oral Activators

In this section you'll find various herbs and supplements reported by individuals to help them activate allylbenzenes.

Latest Oral Activators

These activators are based on the latest ongoing Oilahuasca research. It's been determined that 2 of the primary activation enzymes are CYP2E1 and Estradiol 17beta-dehydrogenase Type 2.

CYP2C9 is no longer considered a primary activation enzyme. While CYP2C9 can 1'-hydroxylate allylbenzenes like CYP2E1 can, CYP2C9 can also O-demethylate allylbenzenes, which is not good. CYP2E1 is only known to 1'-hydroxylate allylbenzenes, and is not known to O-demethylate allylbenzenes. And it's been found that CYP2E1 inhibitors, such as garlic oil, appear to prevent activation.

CYP2D6 appears the be a vital enzyme to inhibit. CYP2D6 is known to O-demethylate and O-demethylenate many compounds, and this is an action that is not good.

CYP3A4 appears the be a vital enzyme to inhibit. CYP3A4 is known to O-demethylate allylbenzenes.

Activator Effectiveness Dosage Notes
Berberine Extremely Potent 300-1000 mg Has been reported to be very helpful in activating elemicin. It is proven to inhibit CYP2C9, CYP2D6, and CYP3A4 in humans, but appears not to inhibit CYP2E1.
Glycerol Extremely Potent when used prior to berberine 5 ml Used to induce CYP2E1. It works well in conjunction with berberine, but is not effective on it's own.
Steviosides Very Potent when used with berberine 100-1000 mg Used to inhibit UGT2B7. It works well in conjunction with berberine, but is not effective on it's own.
Vitamin A Extremely Potent when used prior to berberine 55 mg Used to induce Estradiol 17beta-dehydrogenase Type 2. It works well in conjunction with berberine, but is not effective on it's own.

Older Oral Activators

These older activators have been in use for over 8 years by various individuals.

Activator Effectiveness Dosage Notes
Aniseed (Anise) EO Potent 5-10 drops Works very well for transdermal use. Ground aniseed is known to induce CYP2C9, however it's not known if the essential oil contains the active ingredient or not.
Black Pepper Tea (solids removed) Potent 5-10 grams Has been reported to be very helpful in activating methyl eugenol, dillapiole, elemicin, myristicin. Black pepper tea potently inhibits CYP2D6, and provides the amine piperidine for amination.
Black Seed oil Potent 500 mg It's used to potently inhibit CYP2D6 and inhibit CYP3A4
Calamus EO from Nepal Potent 1-3 drops It can activate elemicin stand alone in some people. Oil from India is typically much less effective. It's not known how it works. Normal calamus oil from India mildly inhibits MAO-A, MAO-B, CYP2D6, and CYP3A4. Oil from Nepal may have addition unknown actions.
Cinnamon EO Potent 200 mg (about 7 drops) used 1 hour before taking allylbenzenes Works for all allylbenzenes. The cinnamaldehyde in cinnamon OE depletes glutathione, a required step for boosting active alkaloid formation of allylbenzenes.
EGCG Potent 200 mg Used to potently inhibit SULT1A1 and SULT1A3
Glucosamine HCl Moderate 700 mg (smaller doses not tested) Inhibits SSAO. Appears to boost the effects of most allylbenzenes. Other SSAO inhibitors such as coffee and phenylethylamine also have the same potentiating effect. It's not known how SSAO inhibitors interact with allylbenzenes or their metabolites. They possibly have some effect on theoretical ammonia based condensation products created in vivo such as 1'-oxoelemicin-Amine
Kudzu Potent 200 mg Used to potently inhibit SULT1A1 and induce 17bHSD2
L-Lysine Moderate 1000 mg Provides piperidine. It appears to help activate all allylbenzenes if used several days in a row before using allylbenzenes.
Pomegranate 40% ellagic acid extract Potent 200-300 mg Used to induce 17bHSD2 (it normally contains gallic acid) and inhibit GST. Gallic acid induces 17bHSD2 but also induces SULT1A1 and SULT1A3 so it must be used with inhibitors of SULT1A1 and SULT1A3
Rooibos 20% gallic acid extract Potent 100-200 mg Used to induce 17bHSD2. Gallic acid induces 17bHSD2 but also induces SULT1A1 and SULT1A3 so it must be used with inhibitors of SULT1A1 and SULT1A3
Rutin Moderate 200 mg Used as an MAO-B inhibitor. It Appears to extends the effects of elemicin.
Star Anise EO (Chinese not Japanese) Potent 5-10 drops Works very well for transdermal use. Ground aniseed induces CYP2C9, and star anise EO contains many similar compounds, but it's not known if star anise EO also induces CYP2C9.
Valerian root oil Potent 3-5 drops Used to potently inhibit UGT2B7 and UGT1A9
Vitamin B3 (niacinamide) Potent 50-100 mg Supplies NAD+ to fuel oxidative 17bHSD2
Vitamin B9 (folic acid) Potent 0.8-1.2 mg Used to induce CYP2C9

Miscellaneous Oral Activators

These have been found to be beneficial in most people. The exact mechanism at play is not known. These might not be effective in everyone.

Activator Effectiveness Dosage Notes
Almonds ? ? Some reports suggest they help nutmeg
Eggs ? ? Some reports suggest they help nutmeg
German chamomile EO Moderate 1-5 drops Can be helpful for elemicin
L-Arginine ? ? More tests need to be done
Star Fruit ? ? It has been used to activate methyl chavicol. It inhibits CYP3A4, and contains some inhibitors of MAO-B, SULT1A1, SULT1A3 and P-Glycoprotein. Because it contains some gallic acid it might also induce 17bHSD2 to some degree.

Controversial Oral Activators

These help some people activate allylbenzenes, but can delay the onset or weaken the effects in other people. The exact reason for this in unknown.
Activator Effectiveness Dosage Notes
Black Pepper Powder Potent 2 grams Very beneficial for nutmeg in some people. Some reports state that nutmeg is ineffective without it. It can delay the onset of the effects of elemicin by a few hours in some people, and weaken the effects.
White Grapefruit juice Potent 1-2 cups It has been reported to help some people get effects from nutmeg. It can greatly weaken and delay the onset of elemicin's effect for several hours in some people.

Transdermal Activators

Activator Effectiveness Dosage Notes
Aniseed (Anise) EO Potent 1-2 drops Works very well for transdermal use with elemicin. Aniseed induces CYP2C9, but it's not known if the essential oil contains the active compound.
German chamomile EO Moderate 1 drop Can be very helpful for elemicin
Calamus EO Potent 1 drop It can activate elemicin stand alone in some people. It works very well transdermally
Star Anise EO (Chinese not Japanese) Potent 1-2 drops Works very well for transdermal use with elemicin. Ground aniseed induces CYP2C9, and star anise EO contains many similar compounds, but it's not known if star anise EO also induces CYP2C9.

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