Oilahuasca Activation

Version 1.2397

For 24 hours prior to using oilahuasca you must follow the Oilahuasca Diet restrictions.

For a list of herbal formulas, supplements, and dietary restrictions known to be effective in obtaining psychedelic effects from allylbenzenes please see the article Oilahuasca Activators.

THIS PAGE EXPLAINS THE OILAHUASCA THEORY. MANY FACTS ARE PRESENTED TO SUPPORT THE OILAHUASCA THEORY. HOWEVER ALL SECTIONS ON THIS PAGE SHOULD BE TREATED AS THEORETICAL UNLESS STATED AS FACT.

THIS IS A WORK IN PROGRESS. IT WILL BE UPDATED AS NEW DATA IS AVAILABLE. TO LEAVE FEEDBACK FOR THIS PAGE USE THE DISCUSS LINK AT THE BOTTOM OF THIS ARTICLE.

THE FACTS BEHIND OILAHUASCA

THIS SECTION IS BACKED BY SCIENTIFIC FACTS

BASIC OILAHUASCA THEORY

THIS SECTION IS THEORETICAL

THE OILAHUASCA ACTIVATION SEQUENCE

The theoretical activation sequence given in this example applies to all allylbenzenes (myristicin, safrole, etc.). In this example we use the allylbenzene elemicin.

There are two distinct sequences which are believed to lead to activity.


OILAHUASCA ACTIVATION VIA ENZYME MANIPULATION

This section details all the known enzymes to induce and inhibit in order to optimize the psychedelic and/or stimulant actions various allylbenzenes are capable of producing when fully activated. In some people allylbenzenes are extremely difficult to activate. Failure to follow these guidelines completely can lead to little or no effects from the various allylbenzenes available.

The single most important enzyme to induce is Estradiol 17beta dehydrogenase type 2 (17bHSD2). This enzyme is required. If 17bHSD2 is inhibited by drinking tea or consuming other drinks, supplements, or food items that inhibit 17bHSD2, then allylbenzenes activation will not take place. Without the action of 17bHSD2, allylbenzenes cannot form alkaloids in vivo.

For additional information on inducers and inhibitors used successfully by several individuals see the article: Oilahuasca Activators

The major human enzymes to induce (+) and inhibit (-) for Oilahuasca Activation.

SSAO 17bHSD2 ADH ALDH UGT1A9 UGT2B7 SULT1A1 SULT1A3 GST
- + + - - - - - -
Cytochrome P450 Enzyme Subfamilies
1A1 1A2 1B1 2A6 2B6 2C19 2C8 2C9 2D6 2E1 2J2 3A4
- +/- - + - + ? + - + - -

TRANSDERMAL USE VERSUS ORAL USE

THIS SECTION IS BASED ON ANECDOTAL DATA ONLY

Tests performed by several individuals have shown that topical application of these allylbenzenes can produce effects that are 5-10 times stronger than that of oral use. When used topically, the onset of the effects are also quicker and the overall duration of the effects are shortened as well. With topical use there are also less side effects.[5]


ALLYLBENZENE POLLS

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ALLYLBENZENE P450 ENZYME SPECIFICS


OILAHUASCA DIET

For 24 hours prior to using oilahuasca you must follow the Oilahuasca Diet restrictions.

Human diet is a major factor in getting oilahuasca working. Many people consume food, drinks and supplements known to inhibit 17bHSD2. Drinks as commonplace as tea and grapefruit juice potently inhibit 17bHSD2. These and other detrimental dietary items explained in this article must be avoided for at least 24 hours prior to using oilahuasca if psychedelic effects are desired. Failure to adhere to these dietary guidelines can completely prevent oilahuasca from working. The 17bHSD2 enzyme is critical for oilahuasca to work. If this enzyme is inhibited by drinking tea or ingesting similar 17bHSD2 inhibitors, it can be impossible to get oilahuasca working. This has been verified by several people. Please adhere to these diet guidelines if you want any success with oilahuasca.


SUPPLEMENTS AND FOODS TO AVOID

Oxidative 17bHSD2 Inhibitors to Avoid

All inhibitors of oxidative 17bHSD2 will prevent activation of allylbenzenes. This enzyme must be induced, not inhibited. It's the single most important enzyme to induce. If oxidative 17bHSD2 is not functioning, allylbenzenes cannot produce psychedelic activity.[5]

Several tests using the potent 17bHSD2 inhibitor quercetin orally in human test subjects have proven that quercetin can completely inactivate allylbenzenes for 3-4 hours if taken prior to taking allylbenzenes.[5] For this reason all sources of quercetin and other potent inhibitors of 17bHSD2 must be avoided.

Naringenin also potently inhibits 17bHSD2. Grapefruit contains large amounts of naringenin, and also prevents the psychedelic action of allylbenzenes if taken before allylbenzenes. Inhibition lasts approximately 4-8 hours.

Galangin, kaempferide, and kaempferol also inhibit 17bHSD2 and need to be avoided.

Here's a list of all known 17bHSD2 inhibitors that should be avoided 4-8 hours prior to using allylbenzenes:

See the articles 17bHSD2, Quercetin and Naringenin for more details and references to the facts stated above.

CYP2A6 Inhibitors to Avoid

CYP2C9 Inhibitors to Avoid

  • Echinacea

CYP2E1 Inhibitors to Avoid

  • Disulfiram
  • Garlic EO
  • Kava

Dimethylamine Boosters to Avoid in Some Cases

It's not known which metabolites of the allylbenzenes are the preferred alkaloid metabolites. Avoid these substances if you specifically want to avoid making too many dimethylamine metabolites.

Anecdotal reports indicate that supplementation with piperidine sources improves activation, and supplementation with dimethylamine sources reduces psychedelic activity. The exact reason for this is currently unknown. Some reports indicate that methyl eugenol and myristicin can be inactive in some cases unless used with piperidine supplements.

The dimethylamine alkaloid metabolites of allylbenzenes are probably more easily destroyed by MAO-A or MAO-B or both. The piperidine metabolites, although probably not psychedelic, may act to protect the dimethylamine metabolites from enzyme destruction.

See the articles Choline, Dimethylamine and Piperidine for more details and references to the facts stated above.


BENEFICIAL SUPPLEMENTS

These have been found to be beneficial based on anecdotal reports. For more details see the article Oilahuasca Activators.

Black Pepper Tea

Black pepper tea provides piperidine. Piperidine supplementation appears to greatly increase the activity of most allylbenzenes. It's not known how this works. Piperidine is known to condense with the 1'-oxo metabolites of allylbenzenes to form piperidine alkaloids such as 1'-oxoelemicin-piperidine, 1'-oxoestragole-piperidine, etc. While these piperidines are probably not psychedelic, they may act as enzyme inhibitors protecting the actual psychedelic metabolites of allylbenzenes from rapid enzyme destruction.

To supplement with piperidine from black pepper, make black pepper tea from about 5-10 grams of black pepper. Brew with 1 cup of hot water. Then filter out the solids. This will provide a substantial amount of piperidine. To make the black pepper tea more palatable, one can use the hot black pepper tea to make Cup Noodles soup.

Note that black pepper contains piperine in addition to piperidine. Piperine is useless for this purpose and should probably be avoided (some tests showed it greatly weakens the effects of elemicin). When making black pepper tea always filter out the solids. This removes nearly all of the piperine. Piperine’s solubility in water is only 9.4 mg per cup. 9.4 mg is too small to have any effect at all. 5 grams of black pepper contains about 500 mg of piperine, but only 9.4 mg will be extracted into 1 cup of water. The rest remains in the solid black pepper grounds. 1 cup of water can hold all the piperidine in black pepper. This is why we extract with water and discard the all solids.

See the articles Black Pepper, 1'-oxoelemicin-piperidine, 1'-Oxoestragole-Piperidine, and Piperine for more details and references to the facts stated above.

Gallic acid

Gallic acid induces 17bHSD2, an essential enzyme required for activation. It also induces SULT1A1 and SULT1A3 and must be pared with potent inhibitors of SULT1A1 and SULT1A3, such as EGCG.

See the articles Gallic acid and 17bHSD2 for more details and references to the facts stated above.

Genistein

Genistein induces 17bHSD2, an essential enzyme required for activation. It also inhibits UGT, SULT, and GST.

See the articles Genistein and 17bHSD2 for more details and references to the facts stated above.

Glucosamine

Acts as an SSAO inhibitor. When using glucosamine to inhibit SSAO it's probably best use it 1 hour before and then again combined with coffee at the time the allylbenzenes are ingested, and a few times periodically throughout the experience to boost the psychedelic effects. Doses of 1500 mg glucosamine HCl have been tested along with coffee producing very good results. Its possible that lower doses are effective but they have not been tested. Glucosamine has a half life of approximately 15 hours. It's SSAO inhibition is likely to last at least 15 hours or more.

See the articles Glucosamine and SSAO for more details and references to the facts stated above.

L-Lysine (causes piperidine formation in vivo)

Piperidine is naturally found in the human body. Piperidine is made mostly in the large intestine (colon) from excess L-lysine. Some people are low in this amine.

Theoretically the body uses piperidine to make piperidine alkaloids from allylbenzenes.

Piperidine supplementation appears to greatly increase the activity of most allylbenzenes. It's not known how this works. Piperidine is known to condense with the 1'-oxo metabolites of allylbenzenes to form piperidine alkaloids such as 1'-oxoelemicin-piperidine, 1'-oxoestragole-piperidine, etc. While these piperidines are probably not psychedelic, they may act as enzyme inhibitors protecting the actual psychedelic metabolites of allylbenzenes from rapid enzyme destruction.

It can take 3 or more hours for food to reach the colon (this varies dramatically from person to person, and depends highly on other contents in the digestive system). For this reason L-lysine supplements should be take several hours before taking allylbenzenes.

To supplement your piperidine levels using L-lysine, take at least 1000 mg or more of L-lysine approximately 3 or more hours before using the allylbenzenes.

See the articles L-Lysine and Piperidine for more details and references to the facts stated above.

Vitamin B9 (Folic Acid)

Folic acid induces CYP2C9. This vitamin has been shown to be very beneficial. Supplement with this vitamin for a few days in a row prior to using allylbenzenes to ensure CYP2C9 is induced.

Vitamin D3

Vitamin D3 induces 17bHSD2, an essential enzyme required for activation. It also induces glutathione and should be pared with a good depleter of glutathioine such as cinnamon oil (which contains cinnamaldehyde).

See the articles 17bHSD2 and Cinnamaldehyde for more details and references to the facts stated above.


THE OLD OSWALD AND PEELE ALLYLBENZENE ACTIVATION THEORY


See Also


Bibliography
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