Monoamine Oxidase B

Monoamine Oxidase B (MAO-B) is an enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. Like MAO-A, it also degrades dopamine.


Inhibitors

Potent Inhibitors Strength Dosage Verified in Man
Apigenin IC50=12.8 µM[3] ? ?
(+)-Catechin IC50=89 µM[1] ? ?
Cyanidin IC50=32 μM[1] ? ?
Delphinidin IC50=31 μM[1] ? ?
Deprenyl IC50=0.1-19 µM[1] 10 mg/day Yes
Emodin IC50=35.4 µM[2] ? ?
(-)-Epicatechin IC50=59 µM[1] ? ?
Formononetin IC50=11 µM[1] ? ?
Hordenine potent enough to activate phenethylamine orally 200 mg Yes
Hydroxytyrosol ? ? ?
Isoquercetrin IC50=12 µM[1] ? ?
Kushenol F IC50=63 µM[1] ? ?
Luteolin IC50=59.7 µM[3] ? ?
Malvidin IC50=19 μM[1] ? ?
Paeonol IC50=42.5 µM[2] ? ?
Pelargonidin IC50=43 μM[1] ? ?
Peonidin IC50=22 μM[1] ? ?
Petunidin IC50=43 μM[1] ? ?
Piperine IC50=91.3 µM[2] ? ?
Quercetin IC50=11 µM[1], IC50=90.0 µM[3] ? ?
Quercetrin IC50=19 µM[1] ? ?
Rutin IC50=4 µM[1] ? ?
Moderate Inhibitors Strength Dosage Verified in Man
Alpha-asarone IC50=338 µM (0.338 mM)[4] ? ?
Beta-asarone IC50=362 µM (0.362 mM)[4] ? ?
Cat's Claw (Chinese) ? ? ?
Cyanidin ? ? ?
Delphinidin ? ? ?
Desmethoxyyangonin ? ? ?
Eugenol IC50=288 µM (0.288 mM)[4] ? ?
FoTi (Polygonum multiflorum) ? ? ?
Malvidin ? ? ?
Methyl Eugenol IC50=269 μM (0.269 mM)[4] ? ?
Moclobemide IC50=480.12 µM[5] ? ?
Naringenin IC50=288 µM[1] ? ?
Peonidin ? ? ?
Rhodiola Rosea ? ? ?
Weak Inhibitors Strength Dosage Verified in Man
Caffeine ? ? ?
Carnosine ? ? ?
Pelargonidin ? ? ?
Petunidin ? ? ?
Inhibitors of Unknown Potency Strength Dosage Verified in Man
Black pepper ? ? ?
Curcumin ? ? ?
Danshensu ? ? ?
Green Tea Extract ? ? ?
Kava ? ? ?
Methysticin ? ? ?
Nepetalactone ? ? ?
Resveratrol ? ? ?
Rosemary extract ? ? ?
Scopoletin ? ? ?
Tribulus Terrestris ? ? ?
Yerba Mate ? ? ?

See Also


Bibliography
1. Anna K. Jäger and Lasse Saaby;
Flavonoids and the CNS; Molecules 2011, 16, 1471-1485; doi:10.3390/molecules16021471; ISSN 1420-3049; (Download Attached PDF Document)
2. Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones.
Kong LD, Cheng CH, Tan RX. PubMed PMID: 15120460
3. Monoamine oxidase inhibitory components from Cayratia japonica.
Han XH, Hong SS, Hwang JS, Lee MK, Hwang BY, Ro JS. PubMed PMID: 17328236
4. Eugenol and its structural analogs inhibit monoamine oxidase A and exhibit antidepressant-like activity.
Tao G, Irie Y, Li DJ, Keung WM. PubMed PMID: 15936201
5. Pyrazoline-based mycobactin analogues as MAO-inhibitors.
Jayaprakash V, Sinha BN, Ucar G, Ercan A. PubMed PMID: 18980841
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