Monoamine Oxidase A


Potent Inhibitors Strength Dosage Verified in Man
Apigenin IC50=1.7 µM[5] ? ?
Eugenol IC50=34.4 µM (0.0344 mM)[6] ? ?
Harmaline Extremely Potent 75-150 mg Yes
Luteolin IC50=4.9 µM[5] ? ?
Moclobemide IC50=3.90 µM[7] 150-300 mg Yes
Paeonol IC50=54.6 µM[4] ? ?
Piperine IC50=49.3 µM[4] ? ?
Quercetin IC50=2.8 µM[5] ? ?
Resveratrol IC50=0.449-26.6 µM[8][1] ? ?
Veraphenol IC50=38.0 µM[1] ? ?
Moderate Inhibitors   Strength Dosage Verified in Man
Alpha-asarone IC50=124 µM (0.124 mM)[6] ? ?
Beta-asarone IC50=142 µM (0.142 mM)[6] ? ?
Methyl Eugenol IC50=110 µM (0.11 mM)[6] ? ?
Weak Inhibitors   Strength Dosage Verified in Man
4-hydroxyphenylacetic acid IC50=20.28 mM[3] ? ?
Vanillic acid IC50=3.89 mM[3] ? ?

See Also

1. Inhibition of xanthine and monoamine oxidases by stilbenoids from Veratrum taliense.
Zhou CX, Kong LD, Ye WC, Cheng CH, Tan RX. PubMed PMID: 11301865
2. Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B.
Alcaro S, Gaspar A, Ortuso F, Milhazes N, Orallo F, Uriarte E, Yáñez M, Borges F. PubMed PMID: 20382016
3. Berry anthocyanins and their aglycons inhibit monoamine oxidases A and B.
Dreiseitel A, Korte G, Schreier P, Oehme A, Locher S, Domani M, Hajak G, Sand PG. PubMed PMID: 19416630
4. Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones.
Kong LD, Cheng CH, Tan RX. PubMed PMID: 15120460
5. Monoamine oxidase inhibitory components from Cayratia japonica.
Han XH, Hong SS, Hwang JS, Lee MK, Hwang BY, Ro JS. PubMed PMID: 17328236
6. Eugenol and its structural analogs inhibit monoamine oxidase A and exhibit antidepressant-like activity.
Tao G, Irie Y, Li DJ, Keung WM. PubMed PMID: 15936201
7. Pyrazoline-based mycobactin analogues as MAO-inhibitors.
Jayaprakash V, Sinha BN, Ucar G, Ercan A. PubMed PMID: 18980841
8. Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) - BioAssay Summary
PubChem AID: 625150
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