Monoamine Oxidase A
Inhibitors
Potent Inhibitors | Strength | Dosage | Verified in Man |
---|---|---|---|
Apigenin | IC50=1.7 µM[5] | ? | ? |
Eugenol | IC50=34.4 µM (0.0344 mM)[6] | ? | ? |
Harmaline | Extremely Potent | 75-150 mg | Yes |
Luteolin | IC50=4.9 µM[5] | ? | ? |
Moclobemide | IC50=3.90 µM[7] | 150-300 mg | Yes |
Paeonol | IC50=54.6 µM[4] | ? | ? |
Piperine | IC50=49.3 µM[4] | ? | ? |
Quercetin | IC50=2.8 µM[5] | ? | ? |
Resveratrol | IC50=0.449-26.6 µM[8][1] | ? | ? |
Veraphenol | IC50=38.0 µM[1] | ? | ? |
Moderate Inhibitors | Strength | Dosage | Verified in Man |
Alpha-asarone | IC50=124 µM (0.124 mM)[6] | ? | ? |
Beta-asarone | IC50=142 µM (0.142 mM)[6] | ? | ? |
Methyl Eugenol | IC50=110 µM (0.11 mM)[6] | ? | ? |
Weak Inhibitors | Strength | Dosage | Verified in Man |
4-hydroxyphenylacetic acid | IC50=20.28 mM[3] | ? | ? |
Vanillic acid | IC50=3.89 mM[3] | ? | ? |
See Also
Bibliography
1. Inhibition of xanthine and monoamine oxidases by stilbenoids from Veratrum taliense.
Zhou CX, Kong LD, Ye WC, Cheng CH, Tan RX. PubMed PMID: 11301865
2. Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B.
Alcaro S, Gaspar A, Ortuso F, Milhazes N, Orallo F, Uriarte E, Yáñez M, Borges F. PubMed PMID: 20382016
3. Berry anthocyanins and their aglycons inhibit monoamine oxidases A and B.
Dreiseitel A, Korte G, Schreier P, Oehme A, Locher S, Domani M, Hajak G, Sand PG. PubMed PMID: 19416630
4. Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones.
Kong LD, Cheng CH, Tan RX. PubMed PMID: 15120460
5. Monoamine oxidase inhibitory components from Cayratia japonica.
Han XH, Hong SS, Hwang JS, Lee MK, Hwang BY, Ro JS. PubMed PMID: 17328236
6. Eugenol and its structural analogs inhibit monoamine oxidase A and exhibit antidepressant-like activity.
Tao G, Irie Y, Li DJ, Keung WM. PubMed PMID: 15936201
7. Pyrazoline-based mycobactin analogues as MAO-inhibitors.
Jayaprakash V, Sinha BN, Ucar G, Ercan A. PubMed PMID: 18980841
8. Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) - BioAssay Summary
PubChem AID: 625150page revision: 26, last edited: 07 Mar 2013 23:52