Monoamine Oxidase B
Monoamine Oxidase B (MAO-B) is an enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. Like MAO-A, it also degrades dopamine.
Inhibitors
Potent Inhibitors | Strength | Dosage | Verified in Man |
---|---|---|---|
Apigenin | IC50=12.8 µM[3] | ? | ? |
(+)-Catechin | IC50=89 µM[1] | ? | ? |
Cyanidin | IC50=32 μM[1] | ? | ? |
Delphinidin | IC50=31 μM[1] | ? | ? |
Deprenyl | IC50=0.1-19 µM[1] | 10 mg/day | Yes |
Emodin | IC50=35.4 µM[2] | ? | ? |
(-)-Epicatechin | IC50=59 µM[1] | ? | ? |
Formononetin | IC50=11 µM[1] | ? | ? |
Hordenine | potent enough to activate phenethylamine orally | 200 mg | Yes |
Hydroxytyrosol | ? | ? | ? |
Isoquercetrin | IC50=12 µM[1] | ? | ? |
Kushenol F | IC50=63 µM[1] | ? | ? |
Luteolin | IC50=59.7 µM[3] | ? | ? |
Malvidin | IC50=19 μM[1] | ? | ? |
Paeonol | IC50=42.5 µM[2] | ? | ? |
Pelargonidin | IC50=43 μM[1] | ? | ? |
Peonidin | IC50=22 μM[1] | ? | ? |
Petunidin | IC50=43 μM[1] | ? | ? |
Piperine | IC50=91.3 µM[2] | ? | ? |
Quercetin | IC50=11 µM[1], IC50=90.0 µM[3] | ? | ? |
Quercetrin | IC50=19 µM[1] | ? | ? |
Rutin | IC50=4 µM[1] | ? | ? |
Moderate Inhibitors | Strength | Dosage | Verified in Man |
Alpha-asarone | IC50=338 µM (0.338 mM)[4] | ? | ? |
Beta-asarone | IC50=362 µM (0.362 mM)[4] | ? | ? |
Cat's Claw (Chinese) | ? | ? | ? |
Cyanidin | ? | ? | ? |
Delphinidin | ? | ? | ? |
Desmethoxyyangonin | ? | ? | ? |
Eugenol | IC50=288 µM (0.288 mM)[4] | ? | ? |
FoTi (Polygonum multiflorum) | ? | ? | ? |
Malvidin | ? | ? | ? |
Methyl Eugenol | IC50=269 μM (0.269 mM)[4] | ? | ? |
Moclobemide | IC50=480.12 µM[5] | ? | ? |
Naringenin | IC50=288 µM[1] | ? | ? |
Peonidin | ? | ? | ? |
Rhodiola Rosea | ? | ? | ? |
Weak Inhibitors | Strength | Dosage | Verified in Man |
Caffeine | ? | ? | ? |
Carnosine | ? | ? | ? |
Pelargonidin | ? | ? | ? |
Petunidin | ? | ? | ? |
Inhibitors of Unknown Potency | Strength | Dosage | Verified in Man |
Black pepper | ? | ? | ? |
Curcumin | ? | ? | ? |
Danshensu | ? | ? | ? |
Green Tea Extract | ? | ? | ? |
Kava | ? | ? | ? |
Methysticin | ? | ? | ? |
Nepetalactone | ? | ? | ? |
Resveratrol | ? | ? | ? |
Rosemary extract | ? | ? | ? |
Scopoletin | ? | ? | ? |
Tribulus Terrestris | ? | ? | ? |
Yerba Mate | ? | ? | ? |
See Also
Bibliography
1. Anna K. Jäger and Lasse Saaby;
Flavonoids and the CNS; Molecules 2011, 16, 1471-1485; doi:10.3390/molecules16021471; ISSN 1420-3049; (Download Attached PDF Document)
2. Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones.
Kong LD, Cheng CH, Tan RX. PubMed PMID: 15120460
3. Monoamine oxidase inhibitory components from Cayratia japonica.
Han XH, Hong SS, Hwang JS, Lee MK, Hwang BY, Ro JS. PubMed PMID: 17328236
4. Eugenol and its structural analogs inhibit monoamine oxidase A and exhibit antidepressant-like activity.
Tao G, Irie Y, Li DJ, Keung WM. PubMed PMID: 15936201
5. Pyrazoline-based mycobactin analogues as MAO-inhibitors.
Jayaprakash V, Sinha BN, Ucar G, Ercan A. PubMed PMID: 18980841page revision: 36, last edited: 07 Mar 2013 23:51