Lysergic Acid Amide Adducts

This section is purely anecdotal, and lacks scientific evidence.

Anecdotal reports indicate that the adduct LSH can form by simply mixing lysergic acid amide and acetaldehyde in acidic solution.

Anecdotal reports also indicate that LSA can form adducts with several other aldehydes, some of which appear to be active, although scientific studies are lacking.

Theoretical Peppermint Adducts

Theoretical adducts prepared with peppermint oil are claimed to create LSH, however the actual content of acetaldehyde in most peppermint oil is very low. It typically contains other aldehydes in higher quantity. If an adduct forms by this process it is very likely an adduct of something other than acetaldehyde. Anecdotal reports indicate that this adduct decomposes over time and should be used shortly after creation. Reports indicate profound effects similar to LSD. Some users have experienced extreme anxiety at higher doses. This adduct is unfortunately notorious for failing to form, and is often used as "proof" that such adducts don't form. Scientific evidence is lacking for both sides of the debate, although subjective effects indicate something is happening beyond placebo when the adduct formation is "successful".

Theoretical Wine Adducts

Theoretical adducts prepared with various types of wines high in acetaldehyde (sherry being a good choice), might actually create some amount of LSH. Some of these wines produce substantial amounts of acetaldehyde. Reports indicate these wines can produce profound effects similar to those of LSD. While there's no doubt that these wines have produced subjective effects somewhat different from LSA, such wines have not been scientifically tested for actual LSH content. It's possible the altered subjective effects are caused by an unknown interaction with compounds in the wine other than acetaldehyde.

Theoretical Cinnamaldehyde Adduct

The cinnamaldehyde adduct is theorized to be an adduct of 2 molecules of LSA and 1 molecule of cinnamaldehyde, rather than a 1:1 ratio. It's theorized to form a 2:1 ratio based on similar cinnamaldehyde adducts such as cinnamylidene-bisacetamide and cinnamylidene-bisphenylacetamide, which are proven to form without the need for a catalyst.

Cinnamylidene-bislysergamide is the theoretical adduct made from 2 molecules of LSA and 1 molecule of cinnamaldehyde.

The less likely adduct to form is cinnamylidene-lysergamide, which is a 1:1 ratio of cinnamaldehyde to LSA.

It's not known if any of these actually form, despite strong anecdotal evidence that some kind of reaction occurs. Scientific studies are sorely lacking.

The theoretical adduct created with cinnamaldehyde made by simply dissolving LSA in cinnamon oil, appears to produce radically different subjective experiences that LSA does alone. It has a rapid onset, rapid peak, and far shorter duration that LSA alone.

Because of the rapid onset, short duration, and radically different subjective effects, many believe this theoretical adduct is solid proof that either adducts form from mixing certain aldehydes with lysergic acid amide, or other chemical reactions occur. Anecdotal reports indicate that this adduct is very stable, lasting many months at room temperature. Scientific data is unfortunately lacking.

In support of this theoretical adduct, it's been noted that cinnamaldehyde is proven to form adducts with several amines, amides, and other compounds without the need for a catalyst. See the article Cinnamaldehyde for more details.

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