Kudzu root was found to contain 12.6 mg/100 g dry weight of genistein and 184 mg/100 g dry weight of daidzein.
Interaction with Psychedelic Compounds
Anecdotal reports indicate that whole kudzu extracts reduce the effects of psychedelics. Unlike whole kudzu which contains puerarin, a compound that interacts with 5-HT2C and also may interact with either 5-HT1A or 5-HT2A receptors, genistein has not been shown to be active at 5-HT1A, 5-HT2A, or 5-HT2C receptors.
1. Phytoestrogens and Health
G. Sarwar Gilani, John J.B. Anderson; The American Oil Chemists Society, 2002; ISBN 1893997324, 9781893997325
2. Puerarin acts through brain serotonergic mechanisms to induce thermal effects.
Chueh FS1, Chang CP, Chio CC, Lin MT.; J Pharmacol Sci. 2004 Dec;96(4):420-7. Epub 2004 Dec 3.; PMID: 15599109
3. NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists.
Overstreet DH, Kralic JE, Morrow AL, Ma ZZ, Zhang YW, Lee DY.; Pharmacol Biochem Behav. 2003 Jun;75(3):619-25.; PMID: [http://www.ncbi.nlm.nih.gov/pubmed/1289567912895679
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