Glutathione
Glutathione.png

It's been shown that α1-adrenoceptor agonists (phenylpropanolamine, phenylephrine) deplete levels of glutathione. It's also been shown that α1-adrenoceptor antagonists (prazosin) help prevent depletion. Yohimbine, the selective α2-adrenoceptor antagonist has no effect.[20]

Glutathione Depleters

Dangerous Glutathione Depleters

Items in this section have been known to cause liver damage after they deplete glutathione levels. Compounds in this section should not be used with other compounds that deplete glutathione.

  • Acetaminophen8[5][6]
  • Acrolein[4]

Compounds that Induce Glutathione Or Prevent Depletion

  • Black Tea (Camellia sinensis)[8]
  • Caffeine[37]
  • Capsaicin (in cayenne)[36]
  • Chamomile recutita (German chamomile)[1]
  • Crassostrea gigas extract[9]
  • Ellagic acid[28]
  • Fish oil[11]
  • Garlic extract[7]
  • Lemon essential oil[31]
  • Linalool (in ho leaf and basil essential oils)[33]
  • N-acetyl-cysteine
  • Ocimum sanctum leaf extract[10]
  • Prazosin[20]
  • Rooibos[26][27]
  • Silymarin (from Milk Thistle)[12][13]
  • Thymoquinone (from Nigella sativa)[21]
  • Vitamin B3 as nicotinic acid[24]
  • Vitamin B3 as nicotinamide (niacinamide)[25]
  • Vitamin B6 + Vitamin B9 (folic acid)[23]

Chemical Properties

PubMed Compound ID: 124886
Molecular Weight: 307.32348 [g/mol]
Molecular Formula: C10H17N3O6S
XLogP3-AA: -4.5
H-Bond Donor: 6
H-Bond Acceptor: 8
IUPAC Name: (2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid
InChI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1
InChIKey: RWSXRVCMGQZWBV-WDSKDSINSA-N
Canonical SMILES: C(CC(=O)NC(CS)C(=O)NCC(=O)O)C(C(=O)O)N
Isomeric SMILES: C(CC(=O)N[CH](CS)C(=O)NCC(=O)O)[CH](C(=O)O)N


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