Glutamate Decarboxylase

Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to GABA and CO2. GAD uses PLP as a cofactor.

Inducers (in vitro rat brain)

Centella asiatica (gotu kola) more than 40% increase at 1 mg/mL [1]
Valeriana officinalis (valerian) more than 40% increase at 1 mg/mL [1]

Inhibitors (in vitro rat brain)

Matricaria recutita (German chamomile) IC50=0.11 mg/mL[1]
Humulus lupulus (hops) IC50=0.65 mg/mL[1]

1. Awad R, Levac D, Cybulska P, Merali Z, Trudeau VL, Arnason JT.
Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system.; Ottawa-Carleton Institute of Biology, University of Ottawa, Ottawa, ON K1N6N5, Canada.; Can J Physiol Pharmacol. 2007 Sep;85(9):933-42. PubMed PMID: 18066140
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