
Glucosamine is an SSAO inhibitor.[2][1]
The oral bioavailability of glucosamine is approximately 26%.[4] Glucosamine sulphate is shown to be well absorbed orally but it undergoes substantial first-pass metabolism. [4]
Glucosamine has a very short serum half-life but has an overall half life of approximately 15 hours in humans orally and can be detected in plasma collected up to 48 hours later.[3] Other studies shown the non-serum half-life of glucosamine was from 28-58 hours.[4]
Glucosamine was shown to reduce glutathione levels in vitro.[5]
Chemical Properties
PubChem Compound ID: 441477
Molecular Weight: 179.17112 [g/mol]
Molecular Formula: C6H13NO5
XLogP3-AA: -2.8
IUPAC Name: (2R,3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol
InChI: InChI=1S/C6H13NO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1,7H2/t2-,3-,4-,5-,6-/m1/s1
InChIKey: MSWZFWKMSRAUBD-QZABAPFNSA-N
Canonical SMILES: C(C1C(C(C(C(O1)O)N)O)O)O
Isomeric SMILES: C([CH]1[C@H]([CH]([C@H]([C@@H](O1)O)N)O)O)O