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69ron69ron 09 Oct 2016 20:49
in discussion Hidden / Per page discussions » CYP3A4

Hi TLT,

I did some research on Panax ginseng's effects in live human test subjects. According to the article below, it had no effects on CYP3A4 in humans test subjects, despite some promising in vitro effects. I run across this a lot where in vitro tests simply don't apply to live humans.

Clinical Assessment of Botanical Supplementation on Cytochrome P450 Phenotypes in the Elderly: St. John’s wort, Garlic oil, Panax ginseng, and Ginkgo biloba

by 69ron69ron, 09 Oct 2016 20:49
69ron69ron 09 Oct 2016 20:08
in discussion Hidden / Per page discussions » Oilahuasca Activators

Hi Bluegrass,

No, that post is not me. I always post as myself, not as a guest.

I'm currently working on researching activation formulas that are based on berberine. It has do date been the most powerful activator I am aware of. Formulas using berberine have activated elemicin at elemicin doses as small as 20 mg for some people.

Berberine has shed new light on activation theory. It very potently inhibits CYP2D6, and also inhibits CYP2C9 and to a lesser degree CYP3A4. This inhibition is proven in both live human test subjects, as well as in vitro lab tests. So it's rock solid reliable data. Tests also show it has no effect on CYP2E1, which is good.

It appears that major allylbenzene inactivation routes are O-demethylation (for compounds like elemicin and myristicin) and O-demethylenation (for compounds like safrole and myristicin). CYP2D6 is notorious for both O-demethylating and O-demethylenating hundreds of compounds. Once an allylbenzene is O-demethylated or O-demethylenated, it becomes extremely difficult for 1'-hydroxylation to take place. So we need to knock out all enzymes capable of O-demethylating or O-demethylenating allylbenzenes. Enzymes known to have these actions are CYP2C9, CYP2D6, CYP3A4 and some others. CYP2E1 doesn't appear to have this action on allylbenzenes. CYP2E1 is only known to 1'-hydroxylate allylbenzenes. That's why CYP2E1 appears to be so beneficial to induce.

One of the good things about using berberine is that it doesn't color up the experience. Most of the other inhibitors that have been shown to have some success such as black pepper, calamus oil, etc., have their own effects, and will color up the experience.

i find there is a very specific middle point between to much cayenne pepper and to little to help activation best.

As has been noted, cayenne pepper (which contains capsaicin) has been both beneficial and detrimental, depending on dosage. Unfortunately, I don't know of any reliable enzyme tests performed on human test subjects that give any real evidence on it's effects in humans. Perhaps some exist, but I haven't found them. All I know of are in vitro tests and some in vivo tests performed on animals, which may not at all apply to humans. Some tests in live rats show it inhibits CYP3A4 and also induces CYP2E1 and CYP3A4. CYP2E1 induction is good. CYP3A4 induction is not good. But humans are not rats. It may have very different effects in humans. If anyone knows of any enzyme effects proven in human test subjects please post about it. That could help us better understand how cayenne pepper works.

The proven stimulant effects that capsaicin has on the human central nervous system are definitely synergistic with psychedelics in general. Capsaicin can moderately boost the effects of most psychedelics if taken after the onset. So this might be one reason for cayenne pepper's perceived effectiveness as an activator. It may actually be more of a synergistic effect rather than an activation effect.

My current research is moving away from supplements that are not proven inhibitors/inducers in human test subjects. So I'm not focusing on capsaicin, unless new data is available. There's just too many unknowns on it's effects in humans.

Piperine has been recently shown to inhibit CYP2E1 in human test subjects. This is probably the reason why whole black pepper is less effective for activation than filtered black pepper tea is. Piperine is a very potent inhibitor of CYP3A4. So a small amount is good, but as the dosage increases it starts inhibiting CYP2E1, which is not good. Filtered black pepper tea contains only a little bit of piperine because of it's very poor water solubility. At this time it's not known why filtered black pepper tea is better than whole black pepper. It's assume that there is another ingredient in black pepper that is a potent activator, and that piperine's presence is muddying the waters. However, it could be that piperine is the sole activator, and that by using filtered tea one simply limits the dosage of the piperine to a level small enough that it inhibits CYP3A4 without also inhibiting CYP2E1. More research needs to be done.

Berberine's inhibition of CYP3A4 is not that great. It needs an admixture to help knock out CYP3A4, but it needs to be one that doesn't also knock out CYP2E1. Small doses of piperine might do the trick. I will research combining small amounts of piperine with berberine, using piperine as a potent CYP3A4 inhibitor in very small doses, and berberine in large doses to inhibit CYP2D6 and CYP2C9. I also plan to research filtered black pepper tea in conjunction with berberine.

by 69ron69ron, 09 Oct 2016 20:08

Hi Corey,

First, my apologies for the very late response. I have extremely limited time these days so I don't visit forums like I used to. I work on this project periodically, and make updates to this site very infrequently when there's new important information available.

I'll address this question, as I believe it's the most important to answer, and I have very limited time at the moment.

Is the information on the Herbpedia pages up to date and thus credible?

The information is being updated slowly. I don't want to add anything new that's not been thoroughly tested or backed by solid facts.

There's ongoing sporadic research being done by various individuals, mostly from people wanting to remain anonymous. The vast majority of the people that contact me via Herbpedia don't post on public forums. In the early days of Oilahuasca, a lot of people were frustrated with the lack of results they had. Most people did not achieve any success whatsoever. Failures were probably in the 95% range. Because of that, the Oilahuasca subject became very controversial, so a lot of forums did not welcome Oilahuascatopic discussions. That's one of the reasons Herbpedia was created.

The single most important bit of recent research stems from tests done using berberine and steviosides. Berberine has greatly increased activation success rates, and reduced the amount of allylbenzenes needed for activation. To this date it's the most powerful activator I am aware of. Steviosides are great to use as UGT2B7 inhibitors. They are proven to be primary substrates of UGT2B7 in humans. Although not yet proven to act as inhibitors in human subjects, since they are proven primary substrates of UGT2B7 in humans, it stands to reason that they will work as competitive inhibitors. Both berberine and steviosides have received a lot of praise from various health organizations, because of their numerous health benefits. So it's great to see these become useful as Oilahuasca activator admixtures.

Another bit of information that has recently changed is that the P450 enzyme CYP2C9 is no longer considered beneficial. In addition to 1'-hydroxylating allylbenzenes it was shown to O-demethylate compounds, an action that is detrimental. Berberine is proven to fairly potently inhibit CYP2C9 in human test subjects, but has been shown to work really well as an activator. This data very clearly shows that CYP2C9 should be inhibited. Tests continue narrowing down the beneficial target P450 enzymes. The current tests I am aware of show that CYP2E1 is probably one of the most important P450 enzymes to induce. CYP2E1 can 1'-hydroxylate allylbenzenes and is not known to O-demethylate compounds. I have noted from hundreds of tests that anything that inhibits CYP2E1 will pull down Oilahuasca success rates.

One problem in the past was that a lot of herbs and supplement inhibitor/inducer data was taken from in vitro tests. For the most part in vitro tests are nearly worthless. Many potent in vitro enzyme inhibitors/inducers turned out to have no effects when tested in humans. So a lot of the previously recommended inhibitors/inducers where either ineffective, or only slightly so. I have since concentrated my research focusing on inhibitors and inducers that have been proven to work in human test subjects. I still use some in vitro test data as a guide to potentially useful inhibitors/inducers, when real human test case data is not available, but I try not to rely on it.

69ron69ron 26 Sep 2016 00:08
in discussion Hidden / Per page discussions » CYP2C9

Thanks. I've updated the page to include information on EPA with a reference to a study showing that it inhibits CYP2C9. The study shows several other polyunsaturated fatty acids also have this action. In addition it shows inhibition for CYP1A2, CYP2E1 and CYP3A4.

by 69ron69ron, 26 Sep 2016 00:08
TLT (guest) 18 Dec 2014 06:08
in discussion Hidden / Per page discussions » Glucuronosyltransferase (UGT)

Recently ive found egcg also inhibits 1a6 & 1a9

by TLT (guest), 18 Dec 2014 06:08
TLT (guest) 10 Dec 2014 22:28
in discussion Hidden / Per page discussions » Glucuronosyltransferase (UGT)

Rifampin is a known potent broad inducer of drug-metabolizing enzymes including UGT1A1

by TLT (guest), 10 Dec 2014 22:28
TLT (guest) 09 Dec 2014 00:48
in discussion Hidden / Per page discussions » CYP3A4

Panax ginseng was the ginseng in the study saying its known to inhibit 3a4 in vivo

by TLT (guest), 09 Dec 2014 00:48
TLT (guest) 09 Dec 2014 00:41
in discussion Hidden / Per page discussions » CYP3A4

In vivo, ginseng is known to inhibit CYP3A4, the primary enzyme involved in the metabolism of imatinib

by TLT (guest), 09 Dec 2014 00:41
TLT (guest) 09 Dec 2014 00:38
in discussion Hidden / Per page discussions » CYP3A4

The Journal of Clinical Pharmacology, 06/20/2011

Malati CY et al. – Fexofenadine pharmacokinetics were unaltered by P ginseng administration. Based on these results, P ginseng appeared to induce CYP3A activity in the liver and possibly the gastrointestinal tract. Patients taking P ginseng in combination with CYP3A substrates with narrow therapeutic ranges should be monitored closely for adequate therapeutic response to the substrate medication.

by TLT (guest), 09 Dec 2014 00:38
TLT (guest) 05 Dec 2014 05:16
in discussion Hidden / Per page discussions » Oilahuasca Activation

^ other psychedelic oil that was suggested is valerian root with high valerenic acid content

by TLT (guest), 05 Dec 2014 05:16
TLT (guest) 03 Dec 2014 06:13
in discussion Hidden / Per page discussions » CYP2C9

Eicosapentaenoic acid on wikipedia says:EPA has an inhibitory effect on CYP2C9 and CYP2C19 hepatic enzymes. At high dose, it may also inhibit the activity of CYP2D6 and CYP3A4, important enzymes involved in drug metabolism.

by TLT (guest), 03 Dec 2014 06:13
TLT (guest) 03 Dec 2014 02:49
in discussion Hidden / Per page discussions » Sulfotransferase (SULT)

ABSTRACT Safrole, present in mace and its essential oils, causes liver tumours in rodents at high dose levels due to formation of DNA reactive 1'-sulfooxysafrole. The present study identifies malabaricone C as a mace constituent able to inhibit safrole DNA adduct formation at the level of sulfotransferasemediated bioactivation. This inhibition was incorporated into physiologically based biokinetic rat and human models. Dosing safrole at 50 mg/kg body weight and malabaricone C-containing mace extract at a ratio reflecting the relative presence in mace, and assuming 100 or 1% uptake of malabaricone Ccontaining mace extract, the model predicted inhibition of 1'-sulfooxysafrole formation for rats and humans by 90 and 100% or 61 and 91%, respectively. To validate the model, mace extract and safrole were co-administered orally to Sprague-Dawley rats. LC-ECI-MS/MS based quantification of DNA adduct levels revealed a significant (p<0.01) 55% reduction of safrole DNA adduct formation by malabaricone C-containing mace extract in the liver of rats exposed to safrole. The data obtained were used to perform a refined risk assessment of safrole. Overall, the results suggest a lower tumour incidence when safrole would be tested within a relevant food matrix containing sulfotransferase inhibitors compared to dosing pure safrole.

From researchgate

by TLT (guest), 03 Dec 2014 02:49
TLT (guest) 02 Dec 2014 03:28
in discussion Hidden / Per page discussions » CYP2E1

Catechins, major polyphenol constituents of green tea, are potent chemopreventive agents against cancers caused by chemical carcinogens in rodents. The effects of four epicatechin derivatives, epigallocatechin gallate (EGCG), epicatechin gallate (ECG), epigallocatechin (EGC) and epicatechin (EC), on the metabolic activation of benzo[a]pyrene (B[a]P), 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP) and aflatoxin B(1) (AFB(1)) by human cytochrome P450 (CYP) were examined. B[a]P, PhIP and AFB(1) were activated by respective human CYP1A1, CYP1A2 and CYP3A4 expressed in the membrane fraction of genetically engineered Salmonella typhimurium (S. typhimurium) TA1538 cells harboring the human CYP and human NADPH-CYP reductase (OR), when the membrane fraction was added to S. typhimurium TA98. Galloylated catechins, ECG and EGCG inhibited the mutagenic activation potently, while EGC and EC showed relatively weak inhibitory effects. Catechins also inhibited the oxidations of typical substrates catalyzed by human CYPs, namely ethoxycoumarin O-deethylation by CYP1A1, ethoxyresorufin O-deethylation by CYP1A2 and midazolam 1'-hydroxylation by CYP3A4. The IC(50) values of catechins for the inhibition of human CYP were roughly the same as those seen in the mutagenic activation. EGCG inhibited other forms of human CYP such as CYP2A6, CYP2C19 and CYP2E1, indicating the non-specific inhibitory effects of EGCG toward human CYPs. Furthermore, EGCG inhibited human NADPH-cytochrome CYP reductase (OR) with a K(i) value of 2.5 microM. These results suggest that the inhibition of the enzyme activity of CYP is accounted for partially by the inhibition of OR.

by TLT (guest), 02 Dec 2014 03:28
TLT (guest) 02 Dec 2014 03:25
in discussion Hidden / Per page discussions » CYP2E1

Copy and paste these on google to see the full report and if they are worth being on your site. Hope I helped!

by TLT (guest), 02 Dec 2014 03:25
TLT (guest) 02 Dec 2014 03:20
in discussion Hidden / Per page discussions » CYP2E1

EGCG inhibited other forms of human CYP such as CYP2A6, CYP2C19 and CYP2E1, indicating the non-specific inhibitory effects of EGCG toward human CYPs.
From pubmed

by TLT (guest), 02 Dec 2014 03:20
TLT (guest) 27 Nov 2014 23:15
in discussion Hidden / Per page discussions » Glucuronosyltransferase (UGT)

Aims: The only FDA approved medication for colorectal cancer (CRC) prevention is celecoxib. Its adverse effects underline the need for safer drugs. Polyphenols like resveratrol are in clinical trials for this purpose. This study aimed at examining effects of resveratrol alone and in combination with curcumin or chrysin on UGT induction in Caco-2 cells. Phytochemical combinations were selected using drug combination analyses of various anti-proliferation ratios of resveratrol + curcumin and resveratrol + chrysin. Main methods: Cell proliferation and UGT1A1 induction assays were carried out with individual polyphenols and combinations. Cell viability was determined with AlamarBlue assays. UGT1A1 mRNA was quantified via real time RT-PCR. UGT activity was determined with 4-methylumbelliferone (4MU) glucuronidation. Key findings: Cell proliferation IC50 estimates (± SE) for resveratrol, curcumin and chrysin were 20.8 ± 1.2, 20.1 ± 1.1 and 16.3 ± 1.3 μM respectively. Combination of anti-proliferative effects showed additivity for resveratrol + chrysin and resveratrol + curcumin. Resveratrol at its IC 50 mediated a four-fold induction of UGT1A1 mRNA in a concentration independent manner. Chrysin at its IC50 induced UGT1A1 expression seven-fold while Curcumin at its IC90 mediated a two-fold induction. The 20 μM:40 μM resveratrol + curcumin and 20 μM :32 μM resveratrol + chrysin combinations mediated the greatest increases in mRNA expression (12 and 22 folds respectively). Significant increase in 4-MU glucuronidation was observed with combinations exhibiting maximal mRNA induction. Significance: Phytochemical combinations can offer greater chemoprevention than single agents. These chemicals might offer safer options than present synthetic therapeutics for CRC prevention. © 2011 Elsevier Inc. All rights reserved.

by TLT (guest), 27 Nov 2014 23:15
TLT (guest) 27 Nov 2014 10:51
in discussion Hidden / Per page discussions » CYP2C8

Abstract

As hops (Humulus lupulus L.) are used in the brewing of beer and by menopausal women as estrogenic dietary supplements, the potential for hop extracts and hop constituents to cause drug-botanical interactions by inhibiting human cytochrome P450 enzymes was investigated. Inhibition of major human cytochrome P450 enzymes by a standardized hop extract and isolated hop prenylated phenols was evaluated using a fast and efficient assay based on ultrahigh pressure liquid chromatography-tandem mass spectrometry. The hop extract at 5 μg/mL inhibited CYP2C8 (93%), CYP2C9 (88%), CYP2C19 (70%), and CYP1A2 (27%) with IC50 values of 0.8, 0.9, 3.3, and 9.4 μg/mL, respectively, but time-dependent inactivation was observed only for CYP1A2. Isoxanthohumol from hops was the most potent inhibitor of CYP2C8 with an IC50 of 0.2 μM, whereas 8-prenylnaringenin was the most potent inhibitor of CYP1A2, CYP2C9 and CYP2C19 with IC50 values of 1.1 μM, 1.1 μM and 0.4 μM, respectively. Extracts of hops contain prenylated compounds such as the flavanones isoxanthohumol and 8-prenylnaringenin and the chalcone xanthohumol that can inhibit CYP450s, especially the CYP2C family, which may affect the efficacy and safety of some CYP2C substrate drugs when co-administered.

From pubmed

by TLT (guest), 27 Nov 2014 10:51

Hello, my name is Corey and SWIM has been reading about Oilahuasca via numerous forums…69ron's forum, drugs-forum, psychonaut, and HerbPedia. SWIM plans on experimenting with Elemi, Nutmeg, Sassafras, Sweet Basil, Parsley Seed and any other essential oils that can produce psychedelic and other psychoactive effects. Does anyone recommend any other essential oils? Also, is using the SWIM acronym necessary on this forum for these oils as none are illegal/controlled (except sassafras)?

Is the information on the Herbpedia pages up to date and thus credible? If not, can someone point SWIM in the direction of up-to-date research regarding diet, enzyme protocol, and active essential oil dosages? SWIM is going to buy these oils and enzyme inhibitors/inducers as well as other supplements than can aid in oilahuasca activation. Perhaps we could make a page for each oil (nutmeg, elemi, sassafras, Sweet Basil, Parsley, etc.) with recommendation for diet, enzyme supplementation, and dosage for each oil. A protocol for each oil's uniqueness, if you will.

Are there any other foods that should be restricted? SWIM found a couple of other foods listed on another forum that were not on the HerbPedia article. These include avoiding Turmeric, Valerian Root, Black Pepper, Cayenne, Cinnamon, Curcumin, Ginkgo Biloba, Pomegranate, Pummelo, Quercetin, Saint John's Wort, White Grapefruit, Eugenol, Starfruit Juice, and all toasted/charred/broiled foods for 1-2 days prior to dosage. A lot of these (black pepper, cinnamon, cayenne, starfruit, pomegranate, valerian) are listed as activators on the herbpedia site, so SWIM was confused.

SWIM noticed that there are two major methods of ingestion, the BP3 and PEA3. Both are similar except for the 3rd step. Via the BP3, one drinks 5-10 grams of filtered black pepper tea, while via the PEA3 method, one takes 300-700 mg phenylehylamine HCL and 200 mg rutin. Has anyone tried using both methods at the same time? Which method is preferred?

As per the cinnamon oil, which is preferred: Cinnamon Bark (Cinnamomum zeylanicum) or Cassia? It says true cinnamon on HerbPedia…is this referring to Cinnamon Bark?

It also mentions how transdermal application may be more effective. Has there been any further research regarding this method of experimentation? Do you still have to utilize the oilahuasca activation methods? Where on the body does one apply it? Same dosage as oral? Are Carrier oils used such as castor, hemp, sesame, coconut, or olive?

Has anyone experimented with the inhalation method via oils vaporized though a diffuser? If so, please list dosages, enyzme inhibitors/inducers used, etc.

What do people think of using Coffee and/or Yerba Mate with oilahuasca. Is it drunken with enzymes inhibitors/deducers (stage 2) or with the allylbenzene oils (stage 3) or after stage 3? SWIM has read coffee/yerba mate is best drunken 30-60 minutes beforehand and also seen where it is best drunken with the allylbenzene essential oils.

SWIM has also read that taking 800 mg of Cayenne Pepper boosts the effects of the oils. If so, how long after should one take it? Has anyone taken Cayenne to help potentiate before?

How many drops of allylbenzene oils (elemi, nutmeg, sweet basil, sassafras, parsley seed) should SWIM try first? I have seen it listed in mg but not in drops…Is there a conversion from mg to drops…this would be determinant on specific gravity, would it not?

Is it important to eat a small amount of food at Stages 1, Stages 2, and Stages 3 to increase absorption? Maybe something high in fat/protein like nuts, peanut butter, or some lecithin?

SWIM has read about extraction techniques for certain chemicals (mainly elemicin) from elemi, nutmeg, etc. Is this worth doing vs. taking the whole oil itself?

What sources do you recommend for your essential oils and/or supplements. I have been planning on using mountain rose herbs, young living, and a few others.

SWIM wants to experiment with all of these oils…SWIM has devised a method based on the knowledge he has accrued the last few days.

48 hours prior to Oilahuasca allylbenzene dosage: SWIM will follow the dietary guidelines posted on HerbPedia:

Folic Acid aka Vitamin B9 will be taken for all 4 days prior and day of using allylbenzene oils.

L-Lysine will be taken for all 4 days prior and day of (3 hours before) using allylbenzene oils.

25 hours before allylbenzene ingestion: SWIM will take 230 mg (7 drops) of cinnamon bark essential oil.

1 hour before allylbenzene ingestion: SWIM will take 196 mg mg (6 drops) of cinnamon bark essential oil. Also take 1500 mg of Glucosamine HCL and 50-100 mg Vitamin D3 Supplement (I read that it's best to take D3 with cinnamon bark oil).

30 minutes before allylbenzene ingestion: SWIM will take 540 mg Black Seed Oil, 208 mg of 50% EGCG, 200 mg Kudzu Root Extract, 61 mg of valerian root EO from China, 0.8 mg Vitamin B9, 200 mg Pomegranate 40% Ellagic Acid Extract, 100 mg Rooibos 20% Gallic Acid Extract, 50 mg Vitamin B3, 1-3 drops Nepalese Calamus EO, 5-10 drops of Star Anise EO from China, 5-10 drops of Anise Seed EO. SWIM has decided not to use Clove Leaf EO or German Chamomile EO at this time, but may in the future. SWIM may drink with yerba mate or coffee here. I am unsure which stage is best for Coffee/Yerba Mate.

Take Allylbenzene Essential Oils (How many drops should SWIM try?) such as Elemi, Sassafras, Nutmeg, Sweet Basil, and Parsley Seed with a cup of Coffee/Yerba Mate, 1500 mg of Glucosamine HCL and either 5-10 grams of Black Pepper tea or 300-700 mg phenylehylamine HCl and 200 mg of Rutin.

How long after allylbenzene ingestion should SWIM take 800 mg of Cayenne?

Should SWIM eat food right after taking the activators and/or allylbenzene essential oils?

SWIM will also take Glucosamine HCL throughout the experience to boost effects. Are there any other supplements SWIM should take during experience? Something high in Vitamin C, perhaps?

SWIM will also exercise after allylbenzene ingestion a bit to help potentiate…

First, SWIM wants to experiment with sassafras essential oil (please find me a source!). Any advice for this particular oil regarding activation techniques?

Hello, my name is Corey and SWIM has been reading about Oilahuasca via numerous forums…69ron's forum, drugs-forum, psychonaut, and HerbPedia. SWIM plans on experimenting with Elemi, Nutmeg, Sassafras, Sweet Basil, Parsley Seed and any other essential oils that can produce psychedelic and other psychoactive effects. Does anyone recommend any other essential oils? Also, is using the SWIM acronym necessary on this forum for these oils as none are illegal/controlled (except sassafras)?

Is the information on the Herbpedia pages up to date and thus credible? If not, can someone point SWIM in the direction of up-to-date research regarding diet, enzyme protocol, and active essential oil dosages? SWIM is going to buy these oils and enzyme inhibitors/inducers as well as other supplements than can aid in oilahuasca activation. Perhaps we could make a page for each oil (nutmeg, elemi, sassafras, Sweet Basil, Parsley, etc.) with recommendation for diet, enzyme supplementation, and dosage for each oil. A protocol for each oil's uniqueness, if you will.

Are there any other foods that should be restricted? SWIM found a couple of other foods listed on another forum that were not on the HerbPedia article. These include avoiding Turmeric, Valerian Root, Black Pepper, Cayenne, Cinnamon, Curcumin, Ginkgo Biloba, Pomegranate, Pummelo, Quercetin, Saint John's Wort, White Grapefruit, Eugenol, Starfruit Juice, and all toasted/charred/broiled foods for 1-2 days prior to dosage. A lot of these (black pepper, cinnamon, cayenne, starfruit, pomegranate, valerian) are listed as activators on the herbpedia site, so SWIM was confused.

SWIM noticed that there are two major methods of ingestion, the BP3 and PEA3. Both are similar except for the 3rd step. Via the BP3, one drinks 5-10 grams of filtered black pepper tea, while via the PEA3 method, one takes 300-700 mg phenylehylamine HCL and 200 mg rutin. Has anyone tried using both methods at the same time? Which method is preferred?

As per the cinnamon oil, which is preferred: Cinnamon Bark (Cinnamomum zeylanicum) or Cassia? It says true cinnamon on HerbPedia…is this referring to Cinnamon Bark?

It also mentions how transdermal application may be more effective. Has there been any further research regarding this method of experimentation? Do you still have to utilize the oilahuasca activation methods? Where on the body does one apply it? Same dosage as oral? Are Carrier oils used such as castor, hemp, sesame, coconut, or olive?

Has anyone experimented with the inhalation method via oils vaporized though a diffuser? If so, please list dosages, enyzme inhibitors/inducers used, etc.

What do people think of using Coffee and/or Yerba Mate with oilahuasca. Is it drunken with enzymes inhibitors/deducers (stage 2) or with the allylbenzene oils (stage 3) or after stage 3? SWIM has read coffee/yerba mate is best drunken 30-60 minutes beforehand and also seen where it is best drunken with the allylbenzene essential oils.

SWIM has also read that taking 800 mg of Cayenne Pepper boosts the effects of the oils. If so, how long after should one take it? Has anyone taken Cayenne to help potentiate before?

How many drops of allylbenzene oils (elemi, nutmeg, sweet basil, sassafras, parsley seed) should SWIM try first? I have seen it listed in mg but not in drops…Is there a conversion from mg to drops…this would be determinant on specific gravity, would it not?

Is it important to eat a small amount of food at Stages 1, Stages 2, and Stages 3 to increase absorption? Maybe something high in fat/protein like nuts, peanut butter, or some lecithin?

SWIM has read about extraction techniques for certain chemicals (mainly elemicin) from elemi, nutmeg, etc. Is this worth doing vs. taking the whole oil itself?

What sources do you recommend for your essential oils and/or supplements. I have been planning on using mountain rose herbs, young living, and a few others.

SWIM wants to experiment with all of these oils…SWIM has devised a method based on the knowledge he has accrued the last few days.

48 hours prior to Oilahuasca allylbenzene dosage: SWIM will follow the dietary guidelines posted on HerbPedia:

Folic Acid aka Vitamin B9 will be taken for all 4 days prior and day of using allylbenzene oils.

L-Lysine will be taken for all 4 days prior and day of (3 hours before) using allylbenzene oils.

25 hours before allylbenzene ingestion: SWIM will take 230 mg (7 drops) of cinnamon bark essential oil.

1 hour before allylbenzene ingestion: SWIM will take 196 mg mg (6 drops) of cinnamon bark essential oil. Also take 1500 mg of Glucosamine HCL and 50-100 mg Vitamin D3 Supplement (I read that it's best to take D3 with cinnamon bark oil).

30 minutes before allylbenzene ingestion: SWIM will take 540 mg Black Seed Oil, 208 mg of 50% EGCG, 200 mg Kudzu Root Extract, 61 mg of valerian root EO from China, 0.8 mg Vitamin B9, 200 mg Pomegranate 40% Ellagic Acid Extract, 100 mg Rooibos 20% Gallic Acid Extract, 50 mg Vitamin B3, 1-3 drops Nepalese Calamus EO, 5-10 drops of Star Anise EO from China, 5-10 drops of Anise Seed EO. SWIM has decided not to use Clove Leaf EO or German Chamomile EO at this time, but may in the future. SWIM may drink with yerba mate or coffee here. I am unsure which stage is best for Coffee/Yerba Mate.

Take Allylbenzene Essential Oils (How many drops should SWIM try?) such as Elemi, Sassafras, Nutmeg, Sweet Basil, and Parsley Seed with a cup of Coffee/Yerba Mate, 1500 mg of Glucosamine HCL and either 5-10 grams of Black Pepper tea or 300-700 mg phenylehylamine HCl and 200 mg of Rutin.

How long after allylbenzene ingestion should SWIM take 800 mg of Cayenne?

Should SWIM eat food right after taking the activators and/or allylbenzene essential oils?

SWIM will also take Glucosamine HCL throughout the experience to boost effects. Are there any other supplements SWIM should take during experience? Something high in Vitamin C, perhaps?

SWIM will also exercise after allylbenzene ingestion a bit to help potentiate…

First, SWIM wants to experiment with sassafras essential oil (please find me a source!). Any advice for this particular oil regarding activation techniques?

bluegrass (guest) 01 Jul 2014 18:13
in discussion Hidden / Per page discussions » Oilahuasca Activators

is that you 69ron?

by bluegrass (guest), 01 Jul 2014 18:13
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