Epoxide Hydrolase

Epoxide Hydrolase functions in detoxification during drug metabolism. It converts epoxides to trans-dihydrodiols, which can be conjugated and excreted from the body.

It's possible that it interferes with Oilahuasca Activation.

Inhibitors	Strength	Dosage	Verified in Man
Calcium [2]	25% inhibition	1 mM	?
Cyclohexene oxide	?	?	?
Nordihydroguiaretic acid	?	?	?
Propenylbenzene epoxide [1]1	18-63% inhibition	1 mM	?
3,3,3-Trichloropropylene oxide	?	?	?
Zink [2]	100% inhibition	1 mM	?

Bibliography

1. Inhibition of epoxide hydrolase from human, monkey, bovine, rabbit and murine liver by trans-3-phenylglycidols.

Dietze EC, Casas J, Kuwano E, Hammock BD.; Comp Biochem Physiol B. 1993 Feb;104(2):309-14.; PMID: 8462281

2. Inhibition of soluble and microsomal epoxide hydrolase by zinc and other metals.

Toxicol Sci. 1999 Nov;52(1):26-32.; Draper AJ1, Hammock BD.; PMID: 10568695

Footnotes

1. Propenylbenzene epoxide has 2 enantiomers: (R,R)-Phenylpropylene oxide and (1S,2S)-1-phenylpropylene oxide. The enantiomer (1S,2S)-1-phenylpropylene oxide is a slightly more potent inhibitor than (R,R)-propenylbenzene epoxide.