CYP2J2
CYP2J2 is expressed in the human small intestine and many extrahepatic tissues.
CYP2J2 is known to metabolize ebastine into hydroxyebastine and terfenadine into terfenadine alcohol.[1]
Other CYP2J2 substrates include astemizole, linoleic acid, arachidonic acid and
testosterone.
Potent Inhibitors | Strength | Dosage | Verified in Man |
---|---|---|---|
Hydroxyebastine [1] | ? | ? | ? |
Moderate Inhibitors | Strength | Dosage | Verified in Man |
Terfenadine Alcohol [1] | ? | ? | ? |
Bibliography
1. Potential of Hydroxyebastine and Terfenadine Alcohol to Inhibit the
Human Cytochrome P450 2J2 Isoform Yune-Jung Yoon and Kwang-Hyeon Liu; J. Korean Soc. Appl. Biol. Chem. 54(5), 659-666 (2011)page revision: 1, last edited: 26 Jan 2013 21:47