CYP2J2 is expressed in the human small intestine and many extrahepatic tissues.

CYP2J2 is known to metabolize ebastine into hydroxyebastine and terfenadine into terfenadine alcohol.[1]

Other CYP2J2 substrates include astemizole, linoleic acid, arachidonic acid and

Potent Inhibitors Strength Dosage Verified in Man
Hydroxyebastine [1] ? ? ?
Moderate Inhibitors Strength Dosage Verified in Man
Terfenadine Alcohol [1] ? ? ?
1. Potential of Hydroxyebastine and Terfenadine Alcohol to Inhibit the
Human Cytochrome P450 2J2 Isoform Yune-Jung Yoon and Kwang-Hyeon Liu; J. Korean Soc. Appl. Biol. Chem. 54(5), 659-666 (2011)
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