CYP2F1 is a member of the Cytochrome P450 enzyme family in humans. CYP2F1 has been detected primarily in the lungs, with only a very weak concentration in the human liver.
The endogenous toxin derived from the fermentation of tryptophan known as 3-methylindole is dehydrogenated into 3-methyleneindolenine by CYP2F1.
CYP2F1 epoxidizes naphthalene to its highly toxic intermediate, naphthalene-
Other known substrates include toluene, propoxycoumarin, pentoxyresoruﬁn, and ethoxycoumarin.
Inhibitors and Inducers
||Verified in Man
1. Drug Metab Dispos. 2008 Jan;36(1):155-62. Epub 2007 Oct 25.
Mechanism-based inactivation of lung-selective cytochrome P450 CYP2F enzymes.
Kartha JS, Yost GS; Department of Pharmacology and Toxicology, 30 South 2000 East, Room 201, University of Utah, Salt Lake City, UT 84112-5820, USA. PubMed PMID: 17962375
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