CYP2C8

CYP2C8 is found in the liver.

CYP2C8 is involved in the metabolism of several compounds including retinol and retinoic acid, arachidonic acid, benzo[a]pyrene, and anticancer drug paclitaxel.

Dehydrogenation Reactions

CYP2C8 was able to dehydrogenate estradiol at the 17beta-hydroxy position creating estrone, an action also carried out by CYP2C9 and CYP2C19.[1]

The enzyme Estradiol 17beta-dehydrogenase can also perform this action on estradiol.

Estradiol	CYP2C19	Estrone
	—->

Inhibitors

Potent Inhibitors	Strength	Dosage	Verified in Man
Star fruit juice	?	?	?
Inhibitors (Potency Unknown)	Strength	Dosage	Verified in Man
White Grapefruit	?	?	?
Naringin	?	?	?
Peppermint oil	?	?	?
Dimethylsulfoxide (DMSO)	?	?	?
Feverfew	?	?	?
Kava	?	?	?
In Vitro Inhibitors Inactive In Man	Strength	Dosage	Verified in Man
Quercetin [2]	?	?	Yes

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Bibliography

1. Role of cytochrome P450 in estradiol metabolism in vitro.

Cheng ZN, Shu Y, Liu ZQ, Wang LS, Ou-Yang DS, Zhou HH. PubMed PMID: 11741520 (Download Attached PDF Document)

2. Effect of quercetin on the pharmacokinetics of rosiglitazone, a CYP2C8 substrate, in healthy subjects.

Kim KA, Park PW, Kim HK, Ha JM, Park JY. PubMed PMID: 16027405

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If an inducer or inhibitor is present on this page and reliable human in vivo studies are available but not shown on this page please leave a comment about it using the Discuss link at the bottom of this page so we can update the inhibitor's data.