CYP2C8
CYP2C8 is found in the liver.
CYP2C8 is involved in the metabolism of several compounds including retinol and retinoic acid, arachidonic acid, benzo[a]pyrene, and anticancer drug paclitaxel.
Dehydrogenation Reactions
CYP2C8 was able to dehydrogenate estradiol at the 17beta-hydroxy position creating estrone, an action also carried out by CYP2C9 and CYP2C19.[1]
The enzyme Estradiol 17beta-dehydrogenase can also perform this action on estradiol.
Estradiol | CYP2C19 | Estrone |
---|---|---|
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Inhibitors
Potent Inhibitors | Strength | Dosage | Verified in Man |
---|---|---|---|
Star fruit juice | ? | ? | ? |
Inhibitors (Potency Unknown) | Strength | Dosage | Verified in Man |
White Grapefruit | ? | ? | ? |
Naringin | ? | ? | ? |
Peppermint oil | ? | ? | ? |
Dimethylsulfoxide (DMSO) | ? | ? | ? |
Feverfew | ? | ? | ? |
Kava | ? | ? | ? |
In Vitro Inhibitors Inactive In Man | Strength | Dosage | Verified in Man |
Quercetin [2] | ? | ? | Yes |
Bibliography
1. Role of cytochrome P450 in estradiol metabolism in vitro.
Cheng ZN, Shu Y, Liu ZQ, Wang LS, Ou-Yang DS, Zhou HH. PubMed PMID: 11741520 (Download Attached PDF Document)
2. Effect of quercetin on the pharmacokinetics of rosiglitazone, a CYP2C8 substrate, in healthy subjects.
Kim KA, Park PW, Kim HK, Ha JM, Park JY. PubMed PMID: 16027405If an inducer or inhibitor is present on this page and reliable human in vivo studies are available but not shown on this page please leave a comment about it using the Discuss link at the bottom of this page so we can update the inhibitor's data.
page revision: 6, last edited: 29 Jan 2013 05:14