CYP2C8 is found in the liver.

CYP2C8 is involved in the metabolism of several compounds including retinol and retinoic acid, arachidonic acid, benzo[a]pyrene, and anticancer drug paclitaxel.

Dehydrogenation Reactions

CYP2C8 was able to dehydrogenate estradiol at the 17beta-hydroxy position creating estrone, an action also carried out by CYP2C9 and CYP2C19.[1]

The enzyme Estradiol 17beta-dehydrogenase can also perform this action on estradiol.

Estradiol CYP2C19 Estrone
Estradiol.png —-> Estrone.png


Potent Inhibitors Strength Dosage Verified in Man
Star fruit juice ? ? ?
Inhibitors (Potency Unknown) Strength Dosage Verified in Man
White Grapefruit ? ? ?
Naringin ? ? ?
Peppermint oil ? ? ?
Dimethylsulfoxide (DMSO) ? ? ?
Feverfew ? ? ?
Kava ? ? ?
In Vitro Inhibitors Inactive In Man Strength Dosage Verified in Man
Quercetin [2] ? ? Yes

1. Role of cytochrome P450 in estradiol metabolism in vitro.
Cheng ZN, Shu Y, Liu ZQ, Wang LS, Ou-Yang DS, Zhou HH. PubMed PMID: 11741520 (Download Attached PDF Document)
2. Effect of quercetin on the pharmacokinetics of rosiglitazone, a CYP2C8 substrate, in healthy subjects.
Kim KA, Park PW, Kim HK, Ha JM, Park JY. PubMed PMID: 16027405

If an inducer or inhibitor is present on this page and reliable human in vivo studies are available but not shown on this page please leave a comment about it using the Discuss link at the bottom of this page so we can update the inhibitor's data.

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