CYP2B6

Cytochrome P450 2B6 (abbreviated as CYP2B6) is an enzyme in humans encoded by the CYP2B6 gene. It's responsible for the metabolism of several drugs.

CYP2B6 is expressed in the liver and in some extrahepatic tissues.

Inhibitors and Inducers

Potent Inhibitors Strength Dosage Verified in Man
Benzyl isothiocyanate [2] ? ? ?
Borneol [1] (mango ginger oil, kachur oil) ? ? ?
Citral (some sources claim moderate inhbition) ? ? ?
Curcumin ? ? ?
Glabridin (in licorice)[2] ? ? ?
Geraniol (some sources claim moderate inhibition) ? ? ?
Isoborneol [1] ? ? ?
Turmeric (contains curcumin) ? ? ?
Licorice (contains glabridin) [2] ? ? ?
Luteolin ? ? ?
Orphenadrine ? ? ?
White Grapefruit ? ? ?
Woohwangcheongsimwon [1] ? ? ?
Moderate Inhibitors Strength Dosage Verified in Man
Alpha-thujone  ? ? ?
Weak Inhibitors Strength Dosage Verified in Man
Capsaicin  ? ? ?
Clopidogrel  ? ? ?
Prasugrel  ? ? ?
Ticlopidine  ? ? ?
Inhibitors (Unknown Potency) Strength Dosage Verified in Man
Clopidogrel  ? ? ?
Glabridin  ? ? ?
Indigo  ? ? ?
3-Isopropenyl-3-methyl diamantane  ? ? ?
2-Isopropenyl-2-methyl adamantane  ? ? ?
Kaempferol  ? ? ?
Menthone  ? ? ?
Naringin   ? ? ?
Phencyclidine  ? ? ?
Sertraline  ? ? ?
ThioTEPA  ? ? ?
Triethylenethiophosphoramide (thiotepa)  ? ? ?
Moderate Inducers Strength Dosage Verified in Man
Efavirenz  ? ? ?
Rifampin  ? ? ?
Weak Inducers Strength Dosage Verified in Man
Nevirapine  ? ? ?
Inducers (Unknown potency) Strength Dosage Verified in Man
DHEA (dehydroepiandrosterone)  ? ? ?
Carbamazepine  ? ? ?
Phenobarbital  ? ? ?
Phenytoin  ? ? ?
Rifampicin  ? ? ?
Bibliography
1. Hyunmi Kim, Kwon-Bok Kim, Hei-Young Ku, Soo-Jin Park, Hoon Choi, Joon-Kwan Moon, Byeoung-Soo Park, Jeong-Han Kim, Sung Su Yea, Choong-Hwan Lee, Hye Suk Lee, Jae-Gook Shin and Kwang-Hyeon Liu;
Identification and Characterization of Potent CYP2B6 Inhibitors in Woohwangcheongsimwon Suspension, an Herbal Preparation Used in the Treatment and Prevention of Apoplexy in Korea and China; Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan 614-735, South Korea; March 10, 2008; DOI: 10.1124/dmd.107.019612
2. Shufeng Zhou, Hwee-Ling Koh, Yihuai Gao,
Zhi-yuan Gong, Edmund Jon Deoon Lee; Herbal bioactivation: The good, the bad and the ugly; Life Sciences 74 (2004) 935 – 968; April 2003; DOI:10.1016/j.lfs.2003.09.035 (Download Attached PDF Document)
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