CYP2A6

Cytochrome P450 2A6 (abbreviated CYP2A6), is a member of the cytochrome P450 mixed-function oxidase system in humans.

CYP2A6 is expressed in the liver and accounts for approximately 4% of total hepatic CYP450.

CYP2A6 Inhibitors and Inducers

Potent Inhibitors Strength Dosage Verified in Man
Almond extract ? 1/2 teaspoon (unverified) ?
Anisaldehyde ? ? ?
Benzaldehyde (found in almond extract, and bitter almond essential oil) ? ? ?
Bergamot EO ? ? ?
Cassia EO ? ? ?
Cinnamaldehyde (found in cinnamon essential oil) ? ? ?
Cinnamon ? ? ?
Cinnamon EO: 5-10 drops ? ? ?
4,4'-Dipyridyl sulfide [1] 96.78% inhibition 10 mM ?
4,4'-Dipyridyl disulfide [1] 97.74% inhibition 10 mM ?
Lemon EO ? ? ?
Lime EO ? ? ?
Limonene ? ? ?
Neroli EO ? ? ?
Nootkatone (found in grape fruit oil) ? ? ?
Orange EO ? ? ?
Petitgrain EO ? ? ?
Safrole (found in sassafras and nutmeg) ? ? ?
Star fruit juice ? ? ?
Tangerine EO ? ? ?
White Grapefruit [3] 1 Liter Yes
Moderate Inhibitors Strength Dosage Verified in Man
Alpha-thujone ? ? ?
Lemongrass EO ? ? ?
Quercetin ? ? ?
Undecylic aldehyde ? ? ?
Weak Inhibitors Strength Dosage Verified in Man
Coumarin ? ? ?
Diethyl disulfide [1] 20.4% inhibition 10 mM ?
Durian Fruit (contains Diethyl disulfide) ? ? ?
Inhibitors ( Unknown Potency) Strength Dosage Verified in Man
Acai berry oil ? ? ?
Bergamottin ? ? ?
Black pepper ? ? ?
caffeic acid ? ? ?
Cannabidiol ? ? ?
Grape Seed Extract ? ? ?
Naringin ? ? ?
Nicotine ? ? ?
Peppermint oil ? ? ?
Inducers Strength Dosage Verified in Man
Curcumin [2] 48.9% induction ? Yes
Turmeric (contains curcumin) ? ? Yes

Bibliography
1. SCREENING OF ORGANOSULFUR COMPOUNDS AS INHIBITORS OF HUMAN CYP2A6
KEN-ICHI FUJITA AND TETSUYA KAMATAKI; Laboratory of Drug Metabolism, Division of Pharmacobio-dynamics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan; 2001
2. Plant polyphenol curcumin significantly affects CYP1A2 and CYP2A6 activity in healthy, male Chinese volunteers;
Ann Pharmacother. 2010 Jun;44(6):1038-45. doi: 10.1345/aph.1M533. Epub 2010 May 18; Chen Y, Liu WH, Chen BL, Fan L, Han Y, Wang G, Hu DL, Tan ZR, Zhou G, Cao S, Zhou HH; Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China. PubMed PMID: 20484172
3. Effect of grapefruit juice on cytochrome P450 2A6 and nicotine renal clearance.
Hukkanen J, Jacob P 3rd, Benowitz NL. PubMed PMID: 17112808

If an inducer or inhibitor is present on this page and reliable human in vivo studies are available but not shown on this page please leave a comment about it using the Discuss link at the bottom of this page so we can update the inhibitor's data.

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