CYP2A6

Cytochrome P450 2A6 (abbreviated CYP2A6), is a member of the cytochrome P450 mixed-function oxidase system in humans.

CYP2A6 is expressed in the liver and accounts for approximately 4% of total hepatic CYP450.

CYP2A6 and CYP1A2 were found to be the most important P450 enzymes involved in 1'-hydroxylation of estragole (methyl chavicol).[6]

CYP2A6 Inhibitors and Inducers

Potent Inhibitors	Strength	Dosage	Verified in Man
Almond extract (contains benzaldehyde)	?	1/2 teaspoon (unverified)	?
Anisaldehyde	?	?	?
Benzaldehyde[5] (found in almond extract, and bitter almond essential oil)	?	?	?
Bergamot EO	?	?	?
Cassia EO	?	?	?
Cinnamaldehyde[4] (found in cinnamon essential oil)	?	?	?
Cinnamon	?	?	?
Cinnamon EO: 5-10 drops	?	?	?
4,4'-Dipyridyl sulfide [1]	96.78% inhibition	10 mM	?
4,4'-Dipyridyl disulfide [1]	97.74% inhibition	10 mM	?
Lemon EO	?	?	?
Lime EO	?	?	?
Limonene	?	?	?
Neroli EO	?	?	?
Nootkatone (found in grape fruit oil)	?	?	?
Orange EO	?	?	?
Petitgrain EO	?	?	?
Safrole (found in sassafras and nutmeg)	?	?	?
Star fruit juice	?	?	?
Tangerine EO	?	?	?
White Grapefruit	[3]	1 Liter	Yes
Moderate Inhibitors	Strength	Dosage	Verified in Man
Alpha-thujone	?	?	?
Lemongrass EO	?	?	?
Quercetin	?	?	?
Undecylic aldehyde	?	?	?
Weak Inhibitors	Strength	Dosage	Verified in Man
Coumarin	?	?	?
Diethyl disulfide [1]	20.4% inhibition	10 mM	?
Durian Fruit (contains Diethyl disulfide)	?	?	?
Inhibitors ( Unknown Potency)	Strength	Dosage	Verified in Man
Acai berry oil	?	?	?
Bergamottin	?	?	?
Black pepper	?	?	?
caffeic acid	?	?	?
Cannabidiol	?	?	?
Grape Seed Extract	?	?	?
Naringin	?	?	?
Nicotine	?	?	?
Peppermint oil	?	?	?
Inducers	Strength	Dosage	Verified in Man
Curcumin [2]	48.9% induction	?	Yes
Turmeric (contains curcumin)	?	?	Yes

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Bibliography

1. SCREENING OF ORGANOSULFUR COMPOUNDS AS INHIBITORS OF HUMAN CYP2A6

KEN-ICHI FUJITA AND TETSUYA KAMATAKI; Laboratory of Drug Metabolism, Division of Pharmacobio-dynamics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan; 2001

2. Plant polyphenol curcumin significantly affects CYP1A2 and CYP2A6 activity in healthy, male Chinese volunteers;

Ann Pharmacother. 2010 Jun;44(6):1038-45. doi: 10.1345/aph.1M533. Epub 2010 May 18; Chen Y, Liu WH, Chen BL, Fan L, Han Y, Wang G, Hu DL, Tan ZR, Zhou G, Cao S, Zhou HH; Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China. PubMed PMID: 20484172

3. Effect of grapefruit juice on cytochrome P450 2A6 and nicotine renal clearance.

Hukkanen J, Jacob P 3rd, Benowitz NL. PubMed PMID: 17112808

4. Inactivation of CYP2A6 by the Dietary Phenylpropanoid trans-Cinnamic Aldehyde (Cinnamaldehyde) and Estimation of Interactions with Nicotine and Letrozole

Jeannine Chan, Tyler Oshiro, Sarah Thomas, Allyson Higa, Stephen Black, Aleksandar Todorovic, Fawzy Elbarbry, and John P. Harrelson PMCID: [ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810772 PMC4810772]

5. More potent inhibition of human CYP2A6 than mouse CYP2A5 enzyme activities by derivatives of phenylethylamine and benzaldehyde.

Rahnasto M, Raunio H, Poso A, Juvonen RO. PMID: 12746108

6. Human cytochrome p450 enzyme specificity for the bioactivation of estragole and related alkenylbenzenes.

Jeurissen SM, Punt A, Boersma MG, Bogaards JJ, Fiamegos YC, Schilter B, van Bladeren PJ, Cnubben NH, Rietjens IM. PMID: 17407329

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If an inducer or inhibitor is present on this page and reliable human in vivo studies are available but not shown on this page please leave a comment about it using the Discuss link at the bottom of this page so we can update the inhibitor's data.