CYP1A1

CYP1A1 is involved in phase I xenobiotic and drug metabolism. It's present predominantly in extrahepatic tissue such as lung, small intestine, placenta and kidney, and at a very low level in the liver.

Potent Inhibitors	Strength	Dosage	Verified in Man
Eugenol	?	?	?
Furafylline	50% Inhibition	IC50=1.89 µM[2]	?
Quercetin	?	?	?
Resveratrol	50% Inhibition	IC50=1.89 µM[2]	?
Inhibitors (unknown potency)	Strength	Dosage	Verified in Man
Apigenin	?	?	?
Bergamottin	?	?	?
Black pepper	?	?	?
Chrysin	?	?	?
Curcumin	?	?	?
Ellagic Acid	?	?	?
Evodia rutaecarpa	?	?	?
Galangin	?	?	?
7-Hydroxyflavone	?	?	?
Imperatorin	?	?	?
Isopimpinellin	?	?	?
Luteolin	?	?	?
Piceatannol	?	?	?
Piperine	?	?	?
Rutaecarpine	?	?	?
Rutin	?	?	?
Sulforaphane	?	?	?
Theaflavin	?	?	?
Turmeric	?	?	?
In Vitro Inhibitors Ineffective In Man	Strength	Dosage	Verified in Man
White Grapefruit	No Effect[1]	3 cups	Yes
Inducers	Strength	Dosage	Verified in Man
Glycerin[1]	?	?	?
Myristicin	?	?	?

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Bibliography

1. Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression.

Lown KS, Bailey DG, Fontana RJ, Janardan SK, Adair CH, Fortlage LA, Brown MB, Guo W, Watkins PB. PubMed PMID: 9153299

2. Cell-based high-throughput bioassays to assess induction and inhibition of CYP1A enzymes.

Yueh MF, Kawahara M, Raucy J. PubMed PMID: 10448061

3. Effects of Purified Glycerol from Biodiesel on Cyp1a1 and Cyp2e1 Expressions in CBA/CA Mice

Szele E, Gombos K, Kovács A, Ember I.; In Vivo. 2011 Mar-Apr;25(2):237-40.; PMID: 21471540