CYP1A1

CYP1A1 is involved in phase I xenobiotic and drug metabolism. It's present predominantly in extrahepatic tissue such as lung, small intestine, placenta and kidney, and at a very low level in the liver.

Potent Inhibitors Strength Dosage Verified in Man
Eugenol ? ? ?
Furafylline 50% Inhibition IC50=1.89 µM[2] ?
Quercetin ? ? ?
Resveratrol 50% Inhibition IC50=1.89 µM[2] ?
Inhibitors (unknown potency) Strength Dosage Verified in Man
Apigenin ? ? ?
Bergamottin ? ? ?
Black pepper ? ? ?
Chrysin ? ? ?
Curcumin ? ? ?
Ellagic Acid ? ? ?
Evodia rutaecarpa ? ? ?
Galangin ? ? ?
7-Hydroxyflavone ? ? ?
Imperatorin ? ? ?
Isopimpinellin ? ? ?
Luteolin ? ? ?
Piceatannol ? ? ?
Piperine ? ? ?
Rutaecarpine ? ? ?
Rutin ? ? ?
Sulforaphane ? ? ?
Theaflavin ? ? ?
Turmeric ? ? ?
In Vitro Inhibitors Ineffective In Man Strength Dosage Verified in Man
White Grapefruit No Effect[1] 3 cups Yes
Inducers Strength Dosage Verified in Man
Glycerin[1] ? ? ?
Myristicin ? ? ?

Bibliography
1. Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression.
Lown KS, Bailey DG, Fontana RJ, Janardan SK, Adair CH, Fortlage LA, Brown MB, Guo W, Watkins PB. PubMed PMID: 9153299
2. Cell-based high-throughput bioassays to assess induction and inhibition of CYP1A enzymes.
Yueh MF, Kawahara M, Raucy J. PubMed PMID: 10448061
3. Effects of Purified Glycerol from Biodiesel on Cyp1a1 and Cyp2e1 Expressions in CBA/CA Mice
Szele E, Gombos K, Kovács A, Ember I.; In Vivo. 2011 Mar-Apr;25(2):237-40.; PMID: 21471540
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