Cuminaldehyde is the main aldehyde found in cumin seed essential oil.

Xanthine Oxidase Inhibition

Cuminaldehyde inhibits xanthine oxidase in vitro with a K(i) value of 120 mM. It's roughly one half the potency of cinnamaldehyde with a K(i) of 64 mM.[1]

Aldose Reductase Inhibition

The IC50 value of cuminaldehyde was 0.00085 mg/mL against rat lens aldose reductase in vitro.[2]

Alpha-Glucosidase Inhibition

Cuminaldehyde inhibited rat alpha-glucosidase with an IC50 of 0.5 mg/mL in vitro.[2]

Chemical Properties

PubChem Compound ID: 326
Molecular Weight: 148.20168 [g/mol]
Molecular Formula: C10H12O
XLogP3: 2.7
H-Bond Donor: 0
H-Bond Acceptor: 1
IUPAC Name: 4-propan-2-ylbenzaldehyde
InChI: InChI=1S/C10H12O/c1-8(2)10-5-3-9(7-11)4-6-10/h3-8H,1-2H3
Canonical SMILES: CC(C)C1=CC=C(C=C1)C=O

1. Scavenging of superoxide anions by spice principles.
Krishnakantha TP, Lokesh BR. PubMed PMID: 8394839
2. Cuminaldehyde: Aldose Reductase and alpha-Glucosidase Inhibitor Derived from Cuminum cyminum L. Seeds.
Lee HS. PubMed PMID: 15796577
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