Cadaverine

Cadaverine is a diamine that occurs as an endogenous amine in humans. It's the decarboxylation product of the essential amino acid L-lysine.

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Formation of piperidine

In vitro tests using mice found that piperidine formed from cadaverine in the large intestine; it was assumed to be created from cadaverine by intestinal bacteria.[2] No formation of piperidine from cadaverine was detected in the brain.[2]

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Toxicity

LD50: 1600 mg/kg oral in mice.[1]

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Chemical Properties

PubChem Compound ID: 273
Molecular Weight: 102.17806 [g/mol]
Molecular Formula: C5H14N2
XLogP3-AA: -0.6
H-Bond Donor: 2
H-Bond Acceptor: 2
IUPAC Name: pentane-1,5-diamine
InChI: InChI=1S/C5H14N2/c6-4-2-1-3-5-7/h1-7H2
InChIKey: VHRGRCVQAFMJIZ-UHFFFAOYSA-N
Canonical SMILES: C(CCN)CCN

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See Also

• L-lysine
• Oilahuasca Activation
• Piperidine
• Piperidines
• Putrescine

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Bibliography

1. Acute oral toxicity and repellency of 933 chemicals to house and deer mice.

Schafer EW Jr, Bowles WA Jr. PubMed PMID 3977403

2. Metabolism of cadaverine and pipecolic acid in brain and other organs of the mouse.

Nomura Y, Schmidt-Glenewinkel T, Giacobini E, Ortiz J. PubMed PMID 6406679