Effects on Enzymes
Rats fed aspartame (1000 mg/kg b.wt.) for 180 days showed significant increase in the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and γ-glutamyl transferase (GGT).
The activity of glutathione peroxidase (GPx), and glutathione reductase (GR) were significantly reduced in the liver.
Depletion of Glutathione
Rats fed aspartame (500 mg/kg b.wt) for 180 days developed significantly decreased levels of glutathione.
1. Effect of long term intake of aspartame on antioxidant defense status in liver.
Abhilash M, Paul MV, Varghese MV, Nair RH. PubMed PMID 21376768
2. Long-term consumption of aspartame and brain antioxidant defense status.
Abhilash M, Sauganth Paul MV, Varghese MV, Nair RH. PubMed PMID 22385158
page revision: 3, last edited: 05 Feb 2013 10:13