Effects on Enzymes

Rats fed aspartame (1000 mg/kg b.wt.) for 180 days showed significant increase in the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and γ-glutamyl transferase (GGT).

The activity of glutathione peroxidase (GPx), and glutathione reductase (GR) were significantly reduced in the liver.[1]

Depletion of Glutathione

Rats fed aspartame (500 mg/kg b.wt) for 180 days developed significantly decreased levels of glutathione.[1][2]

1. Effect of long term intake of aspartame on antioxidant defense status in liver.
Abhilash M, Paul MV, Varghese MV, Nair RH. PubMed PMID 21376768
2. Long-term consumption of aspartame and brain antioxidant defense status.
Abhilash M, Sauganth Paul MV, Varghese MV, Nair RH. PubMed PMID 22385158
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