Aspartame
Effects on Enzymes
Rats fed aspartame (1000 mg/kg b.wt.) for 180 days showed significant increase in the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and γ-glutamyl transferase (GGT).
The activity of glutathione peroxidase (GPx), and glutathione reductase (GR) were significantly reduced in the liver.[1]
Depletion of Glutathione
Rats fed aspartame (500 mg/kg b.wt) for 180 days developed significantly decreased levels of glutathione.[1][2]
Bibliography
1. Effect of long term intake of aspartame on antioxidant defense status in liver.
Abhilash M, Paul MV, Varghese MV, Nair RH. PubMed PMID 21376768
2. Long-term consumption of aspartame and brain antioxidant defense status.
Abhilash M, Sauganth Paul MV, Varghese MV, Nair RH. PubMed PMID 22385158page revision: 3, last edited: 05 Feb 2013 10:13