Allylbenzenes are essential oil derivatives of allylbenzene. Many have well documented medicinal actions. For example, eugenol acts as a local pain reliever, and myristicin acts as an MAO inhibitor.
Several allylbenzenes are well documented to have psychoactivity in man, being either stimulant or psychedelic in action. A vast majority of commonly known psychedelic alkaloids and stimulants are very closely related to the allylbenzenes (amphetamine, MDMA, mescaline, etc.). Several allylbenzenes have been proven to form alkaloid metabolites in vivo under certain circumstances (see Oilahuasca for more details), which is probably the basis of their psychoactivity.
Allylbenzenes Covered in HerbPedia
- 1-Allyl-2,3,4,5-tetramethoxybenzene
- 1'-Hydroxyallylbenzene
- 3,5-Dimethoxyallylbenzene
- 3,5-Dimethoxyphenylprop-2-ene
- 5-allyl-1-methoxy-2,3-dihydroxybenzene
- 6-Hydroxymethyleugenol
- Allylbenzene
- Apiole
- Chavibetol
- Chavicol
- Chavicol-O-glucuronide
- Chavicol-O-sulfate
- Croweacin
- Dillapiole
- Elemicin
- Eugenol
- Gamma-Asarone
- Hydroxychavicol
- Methoxyeugenol
- Methoxyeugenol-O-glucuronide
- Methoxyeugenol-O-sulfate
- Methyl Chavicol
- Methyl Eugenol
- Myristicin
- Oilahuasca Activation
- Oilahuasca Activators
- Osmorhizole
- Safrole
- Sarisan
- Tetramethoxyallylbenzene
Common Allylbenzene Actions
THIS SECTION IS PURELY BASED ON ANECDOTAL DATA.
The actions given are base on full activation normally only achieved by using various Oilahuasca Activators. When used without Oilahuasca Activators many of these allylbenzenes produce mild sedation and side effects. Note that some people are unable to fully activate these allylbenzenes even when using good Oilahuasca Activators. The reason for this is currently unknown.
Allylbenzene | Action | Primary Source |
---|---|---|
3,5-Dimethoxyallylbenzene | Stimulant? | … |
Allylbenzene | Stimulant? | … |
Apiole | Psychedelic | Parsley seed |
Chavibetol | Stimulant | Betel leaf |
Chavicol | Stimulant | Bay leaf, Betel leaf |
Croweacin | Psychedelic? | Crowea saligna, Crowea angustifolia |
Dillapiole | Psychedelic | Dill seed CT Dillapiole |
Elemicin | Psychedelic | Russian tarragon, Elemi, Nutmeg |
Eugenol | Stimulant | Clove, Allspice |
Gamma-Asarone (γ-Asarone) | Psychedelic? | Aniba hostmanniana, Caesulia axillaries, Calamus |
Hydroxychavicol | Stimulant | Betel leaf |
Methoxyeugenol | Stimulant? | Sassafras, Nutmeg |
Methyl chavicol | Psychedelic | Sweet basil, French tarragon |
Methyl eugenol | Psychedelic | Tagetes lucida, Mexican allspice |
Myristicin | Psychedelic | Parsley seed CT Myristicin, Nutmeg |
Osmorhizole | Psychedelic? | Chervil |
Safrole | Psychedelic | Sassafras, Nutmeg |
Sarisan (Asaricin) | Psychedelic? | Piper affinis hispidinervum |
Tetramethoxyallylbenzene | Psychedelic? | Parsley seed |
The 15 Major Psychoactive Allylbenzenes
THIS SECTION IS PURELY BASED ON ANECDOTAL DATA.
The 15 major allylbenzenes are found throughout nature in the essential oils of nutmeg, elemi, sassafras, and several other plants.
The allylbenzenes with methoxy or methylenedioxy groups on the 4 position of the benzene ring appear to produce psychedelic metabolites. Allylbenzenes with a hydroxy group on the 4 position appear to produce stimulant effects only.

position 1 = black (the important allyl side chain, required for conversion to an alkaloid)
position 2 = brown
position 3 = red
position 4 = green (must be a methoxy or methylenedioxy group for psychedelic activity)
position 5 = blue
position 6 = purple
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