In vitro 6-Methoxy-DMT was found to bind to human 5-HT(2) receptor sites.[1] It also binds to human 5-HT(6) receptor sites.

In vitro tests found that 6-Methoxy-DMT bound to rat 5-HT(2A) receptor sites with approximately 1/12 the affinity of DMT, but it's binding affinity was approximately 3 times stronger towards 5-HT(1A) at approximately 1/6 the affinity of DMT.[2]

It's action in man appears to be untested.[2]

The corresponding allylbenzene alkaloid metabolite of this molecule is 1'-oxoestragole-DMA.

Chemical Properties

Synonyms: 6-MeO-DMT; 6-OMe-DMT; 6-Methoxy-N,N-dimethyltryptamine
ChemSpider ID: 23118889
PubChem Compound ID: 12017579
Molecular Weight: 218.29482 [g/mol]
Molecular Formula: C13H18N2O
XLogP3: 2.7
H-Bond Donor: 1
H-Bond Acceptor: 2
IUPAC Name: 2-(6-methoxy-1H-indol-3-yl)-N,N-dimethylethanamine
InChI: InChI=1S/C13H18N2O/c1-15(2)7-6-10-9-14-13-8-11(16-3)4-5-12(10)13/h4-5,8-9,14H,6-7H2,1-3H3
Canonical SMILES: CN(C)CCC1=CNC2=C1C=CC(=C2)OC

See Also

1. Indolealkylamine analogs share 5-HT2 binding characteristics with phenylalkylamine hallucinogens.
Lyon RA, Titeler M, Seggel MR, Glennon RA. PubMed PMID: 3350047
2. Binding of β-carbolines and related agents at serotonin (5-HT2 and 5-HT1A), dopamine (D2) and benzodiazepine receptors
Richard A. Glennon, Malgorzata Dukat, Brian Grella, Seoung-Soo Hong, Luca Costantino, Milt Teitler, Carol Smith, Chris Egan, Katherine Davis, Mariena V. Mattson; 1999; Drug and Alcohol Dependence 60 (2000) 121–132; DOI:10.1016/S0376-8716(99)00148-9
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