Metabolites Of 1'-Hydroxyestragole
This metabolite is created primarily by UGT2B7 and UGT1A9, and to a lesser extend by UGT2B15. These enzymes perform glucuronidation on 1'-hydroxyestragole creating 1'-hydroxyestragole glucuronide. This is a detoxification route.
1'-Oxoestragole is created from 1'-hydroxyestragole by the action of estradiol-17beta-dehydrogenase (17beta-HSD2). This metabolite is then capable of forming adducts with glutathione (GSH) leading to inactivation, or forming adducts with endogenous amines. The latter action is believed to be responsible for the psychedelic effects methyl chavicol is capable of producing in humans under certain conditions. Adducts with glutathione (GSH) and certain endogenous amines form without the need for enzyme interaction. For more details see the article: 1'-Oxoestragole.
PubChem Compound ID: 40003
Molecular Weight: 164.20108 [g/mol]
Molecular Formula: C10H12O2
H-Bond Donor: 1
H-Bond Acceptor: 2
IUPAC Name: 1-(4-methoxyphenyl)prop-2-en-1-ol
Canonical SMILES: COC1=CC=C(C=C1)C(C=C)O