1'-Hydroxyelemicin Glucuronide

1'-Hydroxyelemicin glucuronide is a metabolite of elemicin created from the intermediate metabolite 1'-hydroxyelemicin by the action of glucuronosyltransferase (UGT). The UGT enzymes UGT2B7 and UGT1A9 were found to perform this action on the related compound 1'-hydroxyestragole and are assumed to also carry out this action on 1'-hydroxyelemicin, but it's possible other UGT enzymes perform this action.
Substrate | UGT | End Product |
---|---|---|
1'-Hydroxyelemicin | 1'-Hydroxyelemicin glucuronide | |
![]() |
![]() |
|
Cofactor | Byproduct | |
UDPglucuronate | UDP | |
![]() |
![]() |
Chemical Properties
Molecular Weight: 400.42 [g/mol]
Formula: C18H24O10
XLogP3: 0.45[1]
Canonical SMILES: O(C1[CH]([C@H]([CH]([C@H](O1)C(=O)O)O)O)O)C(C2=CC(=C(C(=C2)OC)OC)OC)C=C
Bibliography
1. XLogP3 values calculated using the Virtual Computational Chemistry Laboratory's
On-line Lipophilicity(logP), Water Solubility(LogS) & pKa Prediction calculator.page revision: 7, last edited: 21 Feb 2013 05:22