This inactive metabolite of elemicin is often reported to be created by CYP1A2 and CYP2A6 primarily, but there are other enzymes said to cause this metabolite to form, with some reports giving very conflicting information. It's possible that many other enzymes can produce this metabolite under certain conditions.

This inactive metabolite is detected in human and rat urine when pure elemicin is ingested. Curiously, 1'-hydroxyelemicin was found to be absent from urine samples when humans or rats ingested nutmeg containing elemicin. The reason for this is unknown but assumed to be related to possible enzyme inhibitors present in nutmeg which prevent the formation of this inactive metabolite of elemicin. [1]

Synonyms: 1'-Hydroxy elemicin
PubChem Compound ID: 3031087
Molecular Weight: 224.25304 [g/mol]
Molecular Formula: C12H16O4
XLogP3: 1.4
IUPAC Name: 1-(3,4,5-trimethoxyphenyl)prop-2-en-1-ol
InChI: InChI=1S/C12H16O4/c1-5-9(13)8-6-10(14-2)12(16-4)11(7-8)15-3/h5-7,9,13H,
Canonical SMILES: COC1=CC(=CC(=C1OC)OC)C(C=C)O

1. Safety evaluation of certain food additives, World Health Organization, 2009, Page 370.
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